Water, Air, & Soil Pollution: Focus

, Volume 8, Issue 1, pp 3–21

A Multiscale Approach for Assessing the Interactions of Environmental and Biological Systems in a Holistic Health Risk Assessment Framework


DOI: 10.1007/s11267-007-9137-7

Cite this article as:
Georgopoulos, P.G. Water Air Soil Pollut: Focus (2008) 8: 3. doi:10.1007/s11267-007-9137-7


Advances in computing processing power and in availability of environmental and biological data have allowed the development and application of comprehensive modeling systems that utilize a holistic, integrated, approach for assessing the interactions of environmental and biological systems across multiple scales of spatiotemporal extent and biological organization. This approach allows mechanism-based environmental health risk assessments in a person-oriented framework, which accounts for simultaneous exposures to contaminants from multiple media, routes, and pathways. The conceptual basis and example applications of the Modeling ENvironment for TOtal Risk (MENTOR), and the DOse–Response Information ANalysis system (DORIAN) are presented.


Comprehensive modeling systemsDORIANMENTOREnvironmental healthRisk assessmentsExposures to mixtures

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  1. 1.Computational Chemodynamics Laboratory (CCL), Environmental and Occupational Health Sciences Institute (EOHSI)UMDNJ Robert Wood Johnson Medical School and Rutgers UniversityPiscatawayUSA