Article

Journal of Signal Processing Systems

, Volume 55, Issue 1, pp 15-23

First online:

Automated Renal Cell Carcinoma Subtype Classification Using Morphological, Textural and Wavelets Based Features

  • Qaiser ChaudryAffiliated withElectrical and Computer Engineering, Georgia Institute of Technology
  • , Syed Hussain RazaAffiliated withElectrical and Computer Engineering, Georgia Institute of Technology
  • , Andrew N. YoungAffiliated withPathology and Laboratory Medicine, Emory University
  • , May D. WangAffiliated withElectrical and Computer Engineering, Georgia Institute of TechnologyBiomedical Engineering, Winship Cancer Institute, Georgia Institute of Technology and Emory University Email author 

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Abstract

We present a new image quantification and classification method for improved pathological diagnosis of human renal cell carcinoma. This method combines different feature extraction methodologies, and is designed to provide consistent clinical results even in the presence of tissue structural heterogeneities and data acquisition variations. The methodologies used for feature extraction include image morphological analysis, wavelet analysis and texture analysis, which are combined to develop a robust classification system based on a simple Bayesian classifier. We have achieved classification accuracies of about 90% with this heterogeneous dataset. The misclassified images are significantly different from the rest of images in their class and therefore cannot be attributed to weakness in the classification system.

Keywords

Renal cell carcinoma Subtype classification Computer-aided diagnosis Tissue image quantification Feature extraction for classification Wavelet Co-occurrence Morphological processing