Virus Genes

, Volume 47, Issue 3, pp 408–413

HIV-1 genotypic diversity and prevalence of drug resistance among treatment naïve HIV-infected individuals in Chengdu of China

  • Peibin Zeng
  • Yu Liu
  • Miao He
  • Zhan Gao
  • Ya Zhou
  • Guohui Bian
  • Hua Shan
  • Jingxing Wang
Article

DOI: 10.1007/s11262-013-0958-3

Cite this article as:
Zeng, P., Liu, Y., He, M. et al. Virus Genes (2013) 47: 408. doi:10.1007/s11262-013-0958-3

Abstract

AIDS is becoming one of leading cause of death among infectious diseases in China. There has been rapidly increasing epidemic of HIV/AIDS in Chengdu since 2003. In order to investigate HIV-1 subtype distribution, drug resistance-associated mutations as well as drug resistance prevalence among treatment naïve HIV-infected individuals in Chengdu of China, 244 HIV confirmed-reactive serum samples were collected from 2007 to 2010, including 165 obtained from blood centers and 79 obtained from hospitals. HIV-1 pol including whole protease, and partial reverse transcriptase genes was amplified, sequenced, and analyzed for subtype determination and drug resistance profile description. A total of 159 amplified sequences which were acquired from 98 sample obtained at blood centers and 61 samples obtained at hospitals had the following genotype distribution: G (0.6 %), F1 (0.6 %), A1 (0.6 %), B (1.9 %), circulating recombinant form (CRF) 01_AE (42.8 %), CRF07_BC (49.1 %), and CRF08_BC (4.4 %). There were 12.2 and 24.6 % samples obtained from blood centers and hospitals, respectively, that harbored drug resistance-associated mutations, and the prevalence of drug resistance among all cases was 1.3 %. This was the first report of HIV molecular surveillance among treatment naïve HIV-infected individuals in Chengdu. Our findings were believed to be helpful on contribution to comprehensive HIV control program in China.

Keywords

HIVTreatment naïveGenotype diversityDrug resistance-associated mutationsPrevalence of drug resistance

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Peibin Zeng
    • 1
  • Yu Liu
    • 1
  • Miao He
    • 1
  • Zhan Gao
    • 1
  • Ya Zhou
    • 1
  • Guohui Bian
    • 1
  • Hua Shan
    • 2
  • Jingxing Wang
    • 1
  1. 1.Research Center of Blood Transfusion-Related Diseases, Institute of Blood TransfusionChinese Academy of Medical SciencesChengduPeople’s Republic of China
  2. 2.The Johns Hopkins HospitalBaltimoreUSA