Article

Virus Genes

, Volume 44, Issue 3, pp 441-449

First online:

Genetic characterization of subtype H1 avian influenza viruses isolated from live poultry markets in Zhejiang Province, China, in 2011

  • Hai-bo WuAffiliated withState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang UniversityInstitute of Bioengineering, Zhejiang Academy of Medical Sciences
  • , Chao-tan GuoAffiliated withInstitute of Bioengineering, Zhejiang Academy of Medical Sciences Email author 
  • , Ru-feng LuAffiliated withDepartment of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University
  • , Li-hua XuAffiliated withAnimal Husbandry and Veterinary Institute, Zhejiang Academy of Agricultural Science
  • , En-kang WoAffiliated withInstitute of Bioengineering, Zhejiang Academy of Medical Sciences
  • , Jin-biao YouAffiliated withInstitute of Bioengineering, Zhejiang Academy of Medical Sciences
  • , Yi-ting WangAffiliated withInstitute of Bioengineering, Zhejiang Academy of Medical Sciences
  • , Qiao-gang WangAffiliated withInstitute of Bioengineering, Zhejiang Academy of Medical Sciences
  • , Nan-ping WuAffiliated withState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University Email author 

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Abstract

Nine avian influenza A viruses (AIVs), H1N2 (n = 2) and H1N3 (n = 7), were isolated from domestic ducks in live poultry markets in Zhejiang Province, Eastern China, in 2011. All viruses were characterized by whole genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis of all eight viral genes showed that the viruses clustered in the Eurasian lineage of influenza A viruses. The hemagglutinin cleavage site of all viruses displayed features of a monobasic cleavage site. Although there was no evidence of re-assortment in subtype H1 AIVs among the avian species and mammalian hosts in this study, continued surveillance is needed considering the important role of the domestic duck in the dissemination and re-assortment of AIVs.

Keywords

Avian influenza viruses Subtype H1 Genetic analysis Domestic ducks Re-assortment