Article

Virus Genes

, Volume 30, Issue 3, pp 341-347

First online:

Genetic Characterization of Rabies Virus Isolates in Korea

  • Yoo Jin ParkAffiliated withLaboratory of Veterinary Microbiology, Department of Veterinary Medicine, Kangwon National University
  • , Myung Kyun ShinAffiliated withGangwon Veterinary Service Laboratory
  • , Hyuk Moo KwonAffiliated withLaboratory of Veterinary Microbiology, Department of Veterinary Medicine, Kangwon National University Email author 

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Abstract

In investigation of the genetic characteristics of rabies viruses in Korea, the nucleotide and deduced amino acid sequences of the nucleoprotein (N) gene were determined in four Korean rabies virus strains obtained from dogs and raccoons, and were compared with published sequences for non-Korean rabies viruses. Three Korean rabies virus isolates had identical nucleotide sequences, and the fourth differed at only one nucleotide position. The Korean virus isolates had 84.5–92.0% nucleotide sequence similarity and 94.0–99.2% amino acid sequence similarity with non-Korean rabies virus isolates. In a phylogenetic tree based on partial nucleotide sequences of the N gene, the Korean rabies viruses formed a single cluster closely related to Arctic rabies viruses (FXCAN, 9141RUS, and 94260NEP). However, they were divergent from other Asian rabies viruses (94256SRL, 8677MAL, ChiNo.7, Phil 12301, and Mdn1278).

Keywords

nucleoprotein gene rabies virus sequence