Virus Genes

, Volume 33, Issue 2, pp 229–234

Characterization of a new Puumala virus genotype associated with hemorrhagic fever with renal syndrome

Original Article

DOI: 10.1007/s11262-005-0061-5

Cite this article as:
Bahr, U., Zeier, M. & Muranyi, W. Virus Genes (2006) 33: 229. doi:10.1007/s11262-005-0061-5


Hantavirus serotype Puumala (PUUV) is the etiologic agent of Nephropathia epidemica (NE), a mild variant of Hemorrhagic Fever with Renal Syndrome (HFRS) in Europe, with lethality rates up to 1% among human patients. The serotype PUUV is composed of numerous geographically restricted strains forming a great number of phylogeographic lineages, sublineages, variants, and clusters. We describe a new, geographically and phylogenetically well-defined pathogenic PUUV sublineage in Southwest Germany (strain Heidelberg/hu) originated from an HFRS patient. The genetic analysis of PUUV strain Heidelberg/hu may contribute in future to better diagnostics, the development of vaccines, and the understanding of the factors that determine hantavirus pathogenesis.


Hantavirus Puumala Genotype Phylogenetic tree HFRS 

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  1. 1.Klinikum der Universität HeidelbergHeidelbergFederal Republic of Germany

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