Original Article

Virus Genes

, Volume 33, Issue 2, pp 229-234

First online:

Characterization of a new Puumala virus genotype associated with hemorrhagic fever with renal syndrome

  • Udo BahrAffiliated withKlinikum der Universität Heidelberg
  • , Martin ZeierAffiliated withKlinikum der Universität Heidelberg
  • , Walter MuranyiAffiliated withKlinikum der Universität Heidelberg Email author 

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Hantavirus serotype Puumala (PUUV) is the etiologic agent of Nephropathia epidemica (NE), a mild variant of Hemorrhagic Fever with Renal Syndrome (HFRS) in Europe, with lethality rates up to 1% among human patients. The serotype PUUV is composed of numerous geographically restricted strains forming a great number of phylogeographic lineages, sublineages, variants, and clusters. We describe a new, geographically and phylogenetically well-defined pathogenic PUUV sublineage in Southwest Germany (strain Heidelberg/hu) originated from an HFRS patient. The genetic analysis of PUUV strain Heidelberg/hu may contribute in future to better diagnostics, the development of vaccines, and the understanding of the factors that determine hantavirus pathogenesis.


Hantavirus Puumala Genotype Phylogenetic tree HFRS