Veterinary Research Communications

, 35:401

Coll2-1, Coll2-1NO2 and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis

Authors

    • Equine Clinic, Department of Companion Animals and EquidsFaculty of Veterinary Medicine of Liege
    • Equine Clinic, Faculty of Veterinary MedicineUniversity of Agricultural Sciences
  • Ann Martens
    • Department of Surgery and Anesthesiology of Domestic Animals, Faculty of Veterinary MedicineGhent University
  • Evita Busschers
    • Veterinair Centrum Someren
  • Thierry Franck
    • Centre for Oxygen Research and DevelopmentUniversity of Liege
  • Michelle Deberg
    • Bone and Cartilage Research UnitUniversity of Liege
  • Yves Henrotin
    • Bone and Cartilage Research UnitUniversity of Liege
  • Laurent Vanderheyden
    • European Centre of the Horse of Mont le Soie
  • Didier Serteyn
    • Equine Clinic, Department of Companion Animals and EquidsFaculty of Veterinary Medicine of Liege
    • Centre for Oxygen Research and DevelopmentUniversity of Liege
    • European Centre of the Horse of Mont le Soie
Original Article

DOI: 10.1007/s11259-011-9487-5

Cite this article as:
Verwilghen, D.R., Martens, A., Busschers, E. et al. Vet Res Commun (2011) 35: 401. doi:10.1007/s11259-011-9487-5

Abstract

The measurement of biomarkers that reflect cartilage breakdown is a powerful tool for investigating joint damage caused by disease or injury. Particularly in cases of osteochondrosis, synovial concentrations of these biomarkers may reveal the presence of osteoarthritic changes. Coll2-1, Coll2-1 NO2 and myeloperoxidase have recently been introduced in equine osteoarticular research but comparison between the concentrations of these markers in OCD affected and healthy joints has not been made. Therefore, this study aimed at reporting the synovial concentrations of these biomarkers in joints affected with osteochondral fragments in the tarsocrural joint compared to unaffected joints. Myeloperoxidase and Coll2-1NO2 revealed to have similar levels between affected joints and controls. However, in contrast to previous studies using C2C the present study demonstrated that synovial levels of Coll2-1 were significantly elevated in tarsocrural joints affected with osteochondrosis. Thus, Coll2-1 may be an earlier marker of cartilage degeneration than other cartilage degradation markers that have been previously used in equine medicine.

Keywords

HorseBiomarkersOsteochondrosisColl2-1MPOCollagen degradation

Copyright information

© Springer Science+Business Media B.V. 2011