Veterinary Research Communications

, Volume 32, Issue 7, pp 509–519

Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle

Authors

  • Eduardo E. Baroni
    • Departamento de Farmacología, Facultad de Ciencias VeterinariasUniversidad Nacional del Litoral
  • Diego C. Díaz
    • Departamento de Farmacología, Facultad de Ciencias VeterinariasUniversidad Nacional del Litoral
  • Eduardo Picco
    • Departamento de Farmacología, Facultad de Ciencias VeterinariasUniversidad Nacional del Litoral
  • Samanta Waxman
    • Cátedra de Farmacología, Facultad de Ciencias VeterinariasUniversidad de Buenos Aires
  • Casilda Rodríguez
    • Cátedra de Farmacología, Facultad de VeterinariaUniversidad Complutense de Madrid
    • Cátedra de Farmacología, Facultad de VeterinariaUniversidad Complutense de Madrid
    • Departamento de Toxicología y Farmacología, Facultad de VeterinariaUniversidad Complutense de Madrid
  • Juan C. Boggio
    • Cátedra de Farmacología, Facultad de Ciencias VeterinariasUniversidad Católica de Córdoba
Original Article

DOI: 10.1007/s11259-008-9053-y

Cite this article as:
Baroni, E.E., Díaz, D.C., Picco, E. et al. Vet Res Commun (2008) 32: 509. doi:10.1007/s11259-008-9053-y

Abstract

Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration (T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in ≥ 7 weeks-old cattle to reach a satisfactory dosage regimen (MIC ≥ 32 μg/mL).

Keywords

Age Cattle Pharmacokinetics PK/PD Sulfamethazine

Copyright information

© Springer Science+Business Media B.V. 2008