Abstract
Purpose
Atherosclerotic cardiovascular complications represent significant cause of mortality in hemodialysis (HD) patients. The aims of this study were to: (a) investigate association of sICAM-1, sVCAM-1, omentin-1 and other non-traditional risk factors with subclinical atherosclerosis; (b) examine the diagnostic value of these specific markers in the early detection of subclinical atherosclerosis; and (c) examine their role as predictors of mortality in group of patients with subclinical atherosclerosis on regular HD.
Materials and methods
Starting from November 2011, a cohort of 210 HD patients participated in this 3-year follow-up study. The subjects were divided into three groups according to the presence of atherosclerosis. Atherosclerotic disease was assessed by measuring carotid intima-media thickness (IMT). Samplings were withdrawn at baseline and thereafter every 12 months until the end of follow-up.
Results
IMT showed weak correlation with sICAM-1 (r = 0.39, P = 0.001), sVCAM-1 (r = 0.27, P = 0.015) and omentin-1 (r = −0.25, P = 0.020), and also omentin-1 showed good correlation with parameters of systolic and diastolic function (r = 0.52, P = 0.001 and r = 0.51, P = 0.001). Multivariate analysis showed that sICAM-1 and sVCAM-1 concentrations were a strong independent correlate of IMT (P = 0.031 and P = 0.010, respectively). The Cox proportional analysis showed that sICAM-1 and omentin-1 concentrations were strong predictors of cardiovascular death (HR 1.85, CI 1.18–2.32, P = 0.021 and HR 4.14, CI 1.38–12.1, P = 0.004, respectively) and that serial measurements of these markers predict IMT progression (HR 1.98, 95 % CI 1.21–2.38, P < 0.002 and HR 2.91, 95 % CI 1.57–4.72, P < 0.001, respectively).
Conclusions
Our study demonstrated that sICAM-1 and omentin-1 levels are strong predictors of cardiovascular death in HD patients with subclinical atherosclerosis.
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Acknowledgments
In this study, the reagents kit for adhesion molecules were provided free of charge by H.K.O. medical systems, Zagreb, and MEDiLAB, Zagreb. Reagents for homocysteine were provided free of charge by Abbott laboratories, Zagreb, and reagents for Lp (a) were provided free of charge by Beckman Coulter, Zagreb.
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Authors wish to confirm that there are no known conflicts of interest associated with this publication. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration.
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Informed consent was obtained from all individual participants included in the study.
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Kocijancic, M., Cubranic, Z., Vujicic, B. et al. Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients. Int Urol Nephrol 48, 1145–1154 (2016). https://doi.org/10.1007/s11255-016-1275-2
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DOI: https://doi.org/10.1007/s11255-016-1275-2