International Urology and Nephrology

, Volume 46, Issue 3, pp 555–561

Apparent diffusion coefficient value as a biomarker reflecting morphological and biological features of prostate cancer

  • Hyeyeol Bae
  • Soichiro Yoshida
  • Yoh Matsuoka
  • Hiroshi Nakajima
  • Eisaku Ito
  • Hiroshi Tanaka
  • Miyako Oya
  • Takayuki Nakayama
  • Hideki Takeshita
  • Toshiki Kijima
  • Junichiro Ishioka
  • Noboru Numao
  • Fumitaka Koga
  • Kazutaka Saito
  • Takumi Akashi
  • Yasuhisa Fujii
  • Kazunori Kihara
Urology - Original Paper

DOI: 10.1007/s11255-013-0557-1

Cite this article as:
Bae, H., Yoshida, S., Matsuoka, Y. et al. Int Urol Nephrol (2014) 46: 555. doi:10.1007/s11255-013-0557-1

Abstract

Purpose

To assess whether there is an association between the apparent diffusion coefficient (ADC) value and the pathological characteristics of prostate cancer.

Methods

The study cohort consisted of 29 consecutive patients with prostate cancer treated with radical prostatectomy. All patients underwent diffusion-weighted MRI before the prostate biopsy. In 42 tumor foci, the associations of the ADC values with the clinicopathological characteristics and Ki-67 labeling index (LI) were analyzed.

Results

High-grade cancers (Gleason score [GS] ≥ 4 + 3), larger cancers (maximum diameter (MD) ≥ 16 mm), and highly proliferating cancers (Ki-67 LI ≥ 4.43 %) had significantly lower ADC values, respectively (P < .001, P = .008, and P = .044, respectively). There was no significant difference in ADC value according to age, prostate-specific antigen, presence of extra-prostatic extension, and intra-tumoral stroma proportion. Multivariate analysis showed that GS, Ki-67 LI, and MD had independent and significant correlations with ADC value (P < .001, P = .006, and P = .002, respectively). Low ADC tumors (<0.52 × 10−3 mm2/s) are likely to be high-grade cancer foci compared with high ADC tumors (relative risk: 65.2). The sensitivity and specificity of the ADC value to predict high-grade cancer foci are 81.8 and 93.5 %, respectively.

Conclusions

A low ADC value reflects the morphological and biological features of prostate cancer. Analyzing the ADC value may make it possible to more precisely predict the cancer aggressiveness of each focus before treatment.

Keywords

Diffusion magnetic resonance imagingProstatic neoplasmsBiological markersKi-67 Antigen

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Hyeyeol Bae
    • 1
  • Soichiro Yoshida
    • 1
  • Yoh Matsuoka
    • 1
  • Hiroshi Nakajima
    • 2
  • Eisaku Ito
    • 2
  • Hiroshi Tanaka
    • 3
  • Miyako Oya
    • 1
  • Takayuki Nakayama
    • 1
  • Hideki Takeshita
    • 1
  • Toshiki Kijima
    • 1
  • Junichiro Ishioka
    • 1
  • Noboru Numao
    • 1
  • Fumitaka Koga
    • 1
  • Kazutaka Saito
    • 1
  • Takumi Akashi
    • 2
  • Yasuhisa Fujii
    • 1
  • Kazunori Kihara
    • 1
  1. 1.Department of Urology, Graduate SchoolTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Department of PathologyTokyo Medical and Dental University Graduate SchoolTokyoJapan
  3. 3.Department of RadiologyOchanomizu Surugadai ClinicTokyoJapan