, Volume 45, Issue 4, pp 1243-1244
Date: 04 May 2013

Comment to Sylwia Olechnowicz-Tietz et al.: the risk of atherosclerosis in patients with chronic kidney disease

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Editor,

We read with interest the recent paper showing that moderate-to-severe low glomerular filtration rate (GFR) is associated with accelerated atherosclerosis in chronic kidney disease (CKD) patients [1]. The study was informative, but few points need clarification.

Firstly, the diagnosis of CDK based on a decreased GFR should rely on multiple measures and a history of the presence of kidney damage 3 months or more. Unfortunately, estimated GFR (eGFR) was calculated using the MDRD equation based on single measures of the serum creatinine in the current study. The authors did not provide the data of kidney damage or decreased kidney function (decreased GFR) before they admitted 3 or more months. Secondly, to our knowledge, the serum creatinine concentration is not a sensitive maker for the estimation of GFR. If the CKD patients with serum creatinine concentration rise above the upper limit of normal, the GFR must decline to approximately half the normal level [2]. All the patients are ...