International Urology and Nephrology

, Volume 46, Issue 1, pp 255–260

Use of a polysulfone hemodialysis membrane may prevent recurrent posterior reversible encephalopathy syndrome in a patient undergoing hemodialysis

Authors

    • Department of Nephrology, Graduate School of Medicine, Institute of Health BiosciencesUniversity of Tokushima
    • Shizuoka City Hospital
  • Takeshi Matsubara
    • Shizuoka City Hospital
    • Department of NephrologyKyoto University Graduate School of Medicine
  • Shuichiro Endo
    • Shizuoka City Hospital
    • Department of NephrologyKyoto University Graduate School of Medicine
  • Taichi Murakami
    • Department of Nephrology, Graduate School of Medicine, Institute of Health BiosciencesUniversity of Tokushima
    • Shizuoka City Hospital
  • Yasuki Hashimoto
    • Shizuoka City Hospital
    • Hashimoto Medical Clinic
Nephrology - Case Report

DOI: 10.1007/s11255-013-0434-y

Cite this article as:
Mima, A., Matsubara, T., Endo, S. et al. Int Urol Nephrol (2014) 46: 255. doi:10.1007/s11255-013-0434-y

Abstract

A 71-year-old woman underwent hemodialysis (HD) treatment for chronic kidney disease. During HD, she developed headache, abnormalities in visual perception, and generalized convulsion. Brain magnetic resonance imaging (MRI) showed T2-hyperintensity lesions in the posterior lobe, and an electroencephalogram showed slow waves in all areas. Twenty days later, the T2-hyperintensity lesions had vanished. Furthermore, perfusion computed tomography (CT) and single-photon emission CT with N-isopropyl[123I]-p-iodoamphetamine (IMP-SPECT) showed no significant abnormalities. The patient was diagnosed with posterior reversible encephalopathy syndrome (PRES) because she displayed typical clinical symptoms and MRI findings. Although several antihypertensive and antiseizure medications were administered, the patient experienced recurrent PRES. Therefore, we used a polysulfone dialyzer to reduce the oxidative stress and inflammation while preserving vascular endothelial function. After use of a polysulfone dialyzer membrane, the patient had no PRES episodes during the clinical course. This is the first study to demonstrate that use of a polysulfone dialyzer membrane instead of a cellulose membrane may prevent recurrent PRES.

Keywords

Posterior reversible encephalopathy syndrome Hemodialysis Polysulfone dialyzer membrane Endothelial dysfunction Oxidative stress Inflammation

Copyright information

© Springer Science+Business Media Dordrecht 2013