International Urology and Nephrology

, Volume 45, Issue 6, pp 1621–1627

Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients

  • Yunkai Bai
  • Hua Xiao
  • Zhenhua Liu
  • Xiaoyan Huang
  • Xinkui Tian
  • Tao Wang
  • Xingwei Zhe
Nephrology - Original Paper

DOI: 10.1007/s11255-013-0431-1

Cite this article as:
Bai, Y., Xiao, H., Liu, Z. et al. Int Urol Nephrol (2013) 45: 1621. doi:10.1007/s11255-013-0431-1

Abstract

Background

Chronic kidney disease (CKD) is associated with high overall and cardiovascular mortality. Numerous studies have reported that increased heart rate is a risk factor for all-cause mortality. We investigated the link between sleep heart rate and artery stiffness in CKD patients.

Methods

In a cross-sectional study, we enrolled 100 prevalent Chinese CKD patients (55 males, aged 52.5 ± 16.40 years). Heart rate was measured with an automatic system. Arterial stiffness was evaluated by using a calibrated tonometer.

Results

Large artery elasticity index (LAEI) was positively correlated with body mass index and hemoglobin but negatively associated with age and systolic blood pressure. Furthermore, LAEI was negatively associated with glomerular filtration rate (GFR) and sleep heart rate. In multivariate regression, LAEI was independently predicted by SBP, BMI, age, sleep heart rate, and gender. Adjusted R2 of the model was 0.486.

Conclusion

Elevated sleep heart rate is significantly associated with increased arterial stiffness in CKD patients. Further investigation is needed to explore the potential benefits of sleep heart rate lowering therapy in this patient group.

Keywords

Arterial stiffnessHeart rateCVD

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Yunkai Bai
    • 1
  • Hua Xiao
    • 1
  • Zhenhua Liu
    • 1
  • Xiaoyan Huang
    • 2
  • Xinkui Tian
    • 3
  • Tao Wang
    • 3
  • Xingwei Zhe
    • 1
  1. 1.Division of NephrologyFirst Affiliated Hospital of Kunming Medical UniversityKunmingChina
  2. 2.Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and TechnologyKarolinska InstitutetStockholmSweden
  3. 3.Division of NephrologyPeking University Third HospitalBeijingChina