, Volume 45, Issue 5, pp 1495-1500
Date: 01 May 2012

Wiskott–Aldrich syndrome with IgA nephropathy: a case report and literature review

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


The pathogenesis of renal involvement in Wiskott–Aldrich syndrome (WAS) is unclear and renal outcome is generally poor in such situations. Here we present the case of an 8-year-old boy with WAS who developed hematuria, proteinuria, and declining renal function that did not improve with the combined use of immunosuppressive agents and angiotensin-converting-enzyme inhibitor. Renal pathology revealed IgA nephropathy (IgAN). The patient underwent splenectomy for refractory thrombocytopenia. The proteinuria remitted and renal function improved after splenectomy, long-term antibiotic prophylaxis, and tapering of immunosuppressive agents.