International Urology and Nephrology

, Volume 44, Issue 5, pp 1549–1557

Kidney transplantation after desensitization in sensitized patients: a Korean National Audit

  • Kyu Ha Huh
  • Beom Seok Kim
  • Jaeseok Yang
  • Jeongmyung Ahn
  • Myung-Gyu Kim
  • Jae Berm Park
  • Jong Man Kim
  • Byung-Ha Chung
  • Joong Kyung Kim
  • Jin Min Kong
Nephrology – Original Paper

DOI: 10.1007/s11255-012-0169-1

Cite this article as:
Huh, K.H., Kim, B.S., Yang, J. et al. Int Urol Nephrol (2012) 44: 1549. doi:10.1007/s11255-012-0169-1

Abstract

Introduction

The number of end-stage renal disease (ESRD) patients with preformed antibodies waiting for a kidney transplant has been increasing lately. We conducted a nationwide study on the outcomes of kidney transplantation after desensitization in Korea.

Methods

Six transplant centers have run desensitization programs. The patients who underwent living donor kidney transplantation after desensitization from 2002 to 2010 were retrospectively analyzed.

Results

A total of 86 cases were enrolled. Thirty-five of these were cases of re-transplantation (40.7 %). Indications of desensitization were positive complement-dependent cytotoxicity (CDC) cross-match responses (CDC+, 36.0 %), positive flow-cytometric cross-match responses (FCX+, 54.7 %), and positive donor-specific antibodies (DSA+, 8.1 %). The desensitization protocols used pre-transplant plasmapheresis (95.3 %), intravenous immunoglobulin (62.8 %), and rituximab (67.4 %). Acute rejection occurred in 18 patients (20.9 %), graft failure occurred in 4 patients, and the 3-year graft survival rate was 93.8 %. The presence of DSA increased the acute rejection rate (P = 0.015) and decreased the 1-year post-transplant estimated glomerular filtration rate (P = 0.006). Although rejection-free survival rates did not differ significantly between the CDC+ and FCX+ groups, the 1-year estimated glomerular filtration rate was lower in the CDC+ group (P = 0.010). Infectious and significant bleeding complications occurred in 15.5 % and 4.7 % of cases, respectively.

Conclusion

Kidney transplantation after desensitization had good graft outcomes and tolerable complications in Korea, and therefore, this therapy can be recommended for sensitized ESRD patients.

Keywords

Immunologic desensitizationKidney transplantationRejection

Copyright information

© Springer Science+Business Media, B.V. 2012

Authors and Affiliations

  • Kyu Ha Huh
    • 1
  • Beom Seok Kim
    • 2
  • Jaeseok Yang
    • 3
    • 4
  • Jeongmyung Ahn
    • 5
  • Myung-Gyu Kim
    • 3
  • Jae Berm Park
    • 6
  • Jong Man Kim
    • 7
  • Byung-Ha Chung
    • 8
  • Joong Kyung Kim
    • 9
  • Jin Min Kong
    • 5
  1. 1.Department of SurgeryYonsei University College of MedicineSeoulRepublic of Korea
  2. 2.Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea
  3. 3.Transplantation CenterSeoul National University HospitalSeoulRepublic of Korea
  4. 4.Transplantation Research InstituteSeoul National University College of MedicineSeoulRepublic of Korea
  5. 5.Department of Internal MedicineMaryknoll Medical CenterBusanKorea
  6. 6.Department of SurgeryUniversity of Ulsan College of MedicineSeoulSouth Korea
  7. 7.Department of SurgerySungkyunkwan University School of MedicineSeoulRepublic of Korea
  8. 8.Department of Internal MedicineThe Catholic University of KoreaSeoulSouth Korea
  9. 9.Department of MedicineBong Seng HospitalBusanKorea