Nephrology - Original Paper

International Urology and Nephrology

, Volume 44, Issue 3, pp 945-954

Roma ethnicity and clinical outcomes in kidney transplant recipients

  • Miklos Z. MolnarAffiliated withInstitute of Pathophysiology, Semmelweis UniversityInstitute of Behavioral Sciences, Semmelweis UniversityHarold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Email author 
  • , Robert M. LangerAffiliated withDepartment of Transplantation and Surgery, Semmelweis University
  • , Adam RemportAffiliated withDivision of Nephrology, Szent Imre Hospital
  • , Maria E. CziraAffiliated withInstitute of Behavioral Sciences, Semmelweis University
  • , Katalin RajczyAffiliated withHungarian National Blood Transfusion Servicer
  • , Kamyar Kalantar-ZadehAffiliated withHarold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLAUCLA David Geffen School of Medicine
  • , Csaba P. KovesdyAffiliated withDivision of Nephrology, Salem VA Medical CenterDivision of Nephrology, University of Virginia
  • , Marta NovakAffiliated withInstitute of Pathophysiology, Semmelweis UniversityInstitute of Behavioral Sciences, Semmelweis UniversityDepartment of Psychiatry, University Health Network, University of Toronto
  • , Istvan MucsiAffiliated withInstitute of Pathophysiology, Semmelweis UniversityInstitute of Behavioral Sciences, Semmelweis UniversityDivision of Nephrology, Department of Medicine, McGill University Health Center
    • , Laszlo RosivallAffiliated withInstitute of Pathophysiology, Semmelweis University

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Abstract

Background

Racial and ethnic disparities among North American patients with chronic kidney disease have received significant attention. In contrast, little is known about health-related outcomes of patients with end-stage renal disease among the Roma minority, also known as gypsies, compared to Caucasian individuals. We prospectively assessed the association between Roma ethnicity and long-term clinical outcomes in kidney transplant recipients.

Methods

In a prevalent cohort of renal transplant recipients, followed up over a median of 94 months, we prospectively collected socio-demographic, medical (and transplant related) characteristics and laboratory data at baseline from 60 Roma and 1,003 Caucasian patients (mean age 45 (SD = 11) and 49 (SD = 13) years, 33 and 41% women, 18 and 17% with diabetes mellitus, respectively). Survival analyses examined the associations between Roma ethnicity and all-cause mortality and death-censored graft loss or death with functioning renal allograft.

Results:

During the follow-up period, 341 patients (32%) died. Two-hundred eighty (26%) patients died with a functioning graft and 201 patients (19%) returned to dialysis. After multivariable adjustments, Roma ethnicity was associated with 77% higher risk of all-cause mortality (Hazard Ratio (HR): 1.77; 95% confidence interval (CI): 1.02, 3.07), two times higher risk of mortality with functioning graft (2.04 [1.17–3.55]) and 77% higher risk of graft loss (1.77 [1.01–3.13]), respectively.

Conclusions

Roma ethnicity is independently associated with increased mortality risk and worse graft outcome in kidney transplant recipients. Further studies should identify the factors contributing to worse outcomes among Roma patients.

Keywords

Roma ethnicity Kidney transplantation Mortality, graft loss