International Urology and Nephrology

, Volume 44, Issue 2, pp 425–429

Solifenacin objectively decreases urinary sensation in women with overactive bladder syndrome

  • Lior Lowenstein
  • Kimberly Kenton
  • Elizabeth R. Mueller
  • Linda Brubaker
  • Edmond Sabo
  • Ramón A. Durazo-Arivzu
  • Mary P. FitzGerald
Urology – Original Paper

DOI: 10.1007/s11255-011-0059-y

Cite this article as:
Lowenstein, L., Kenton, K., Mueller, E.R. et al. Int Urol Nephrol (2012) 44: 425. doi:10.1007/s11255-011-0059-y

Abstract

Purpose

To evaluate the test–retest reliability of a device that measures urinary sensation during cystometry, and to use that device to determine whether treatment of overactive bladder syndrome (OAB) with solifenacin is associated with a change in urinary sensation.

Methods

Overall 15 women were recruited for this study, ten women with OAB and urodynamically demonstrated detrusor overactivity and five controls without OAB underwent filling cystometry twice with contemporaneous, continuous recording of urinary sensation. Women with OAB received solifenacin 10 mg daily during the weeks between testing. We compared the areas under the initial and repeat sensation-volume curves.

Results

While taking solifenacin, the maximum cystometric capacity increased from 329 ± 168 ml to 464 ± 123 ml (P < 0.002), and the area under the bladder volume-sensation curve decreased (P < 0.0001). Untreated controls did not exhibit these changes.

Conclusion

We present psychometric data demonstrating improved bladder sensation during the treatment of OAB with solifenacin. If clinical correlations are confirmed by future study, such urinary sensation measures may prove useful as assessment, treatment predictor, or outcome measures in OAB research and/or clinical care.

Keywords

Antimuscarinic Urgency Urgeometer Validity 

Copyright information

© Springer Science+Business Media, B.V. 2011

Authors and Affiliations

  • Lior Lowenstein
    • 1
  • Kimberly Kenton
    • 2
  • Elizabeth R. Mueller
    • 2
  • Linda Brubaker
    • 2
  • Edmond Sabo
    • 3
  • Ramón A. Durazo-Arivzu
    • 4
  • Mary P. FitzGerald
    • 2
  1. 1.Department of Obstetrics and GynecologyRambam Health Care Campus, Technion Faculty of MedicineHaifaIsrael
  2. 2.Division of Female Pelvic Medicine and Reconstructive SurgeryLoyola Medical CenterMaywoodUSA
  3. 3.Department of PathologyRambam Health Care Campus, Technion Faculty of MedicineHaifaIsrael
  4. 4.Department of Preventive Medicine and EpidemiologyLoyola Medical CenterMaywoodUSA

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