International Urology and Nephrology

, Volume 44, Issue 2, pp 401–408

Effects of micronised purified flavonoid fraction on pain, semen analysis and scrotal color Doppler parameters in patients with painful varicocele; results of a randomized placebo-controlled study

  • Haluk Söylemez
  • Süleyman Kiliç
  • Murat Atar
  • Necmettin Penbegül
  • Ahmet Ali Sancaktutar
  • Yaşar Bozkurt
Urology – Original Paper

DOI: 10.1007/s11255-011-0038-3

Cite this article as:
Söylemez, H., Kiliç, S., Atar, M. et al. Int Urol Nephrol (2012) 44: 401. doi:10.1007/s11255-011-0038-3

Abstract

Aim

Aim of this study is to evaluate the effects of micronised purified flavonoid fraction (Daflon®) on pain, semen analysis and color Doppler parameters in patients with painful varicocele.

Materials and methods

Forty varicocele patients whom have normal sperm concentration (>20 million/ml) were involved in the study. The patients were divided into two groups such as Daflon (n = 20) and placebo (n = 20) group. Pain score, semen analyses and Doppler sonography were performed in all patients before and after the treatment.

Results

In the first group, mean pain scores at 1, 3, 6 and 12 months were 1.80 ± 1.32, 1.15 ± 0.93, 1.05 ± 0.95 and 0.95 ± 0.89, respectively, all were significantly lower (P < 0.001 for each) than baseline (5.25 ± 1.07). While semen volume, total sperm count, sperm concentration and morphology were not changed significantly, the motility of sperm increased significantly (P = 0.015) due to decrease in grade 1 sperms at the 6th month in the first group. Reflux time of left spermatic vein during the Valsalva maneuver decreased significantly (P < 0.001).

Conclusions

Results of this study suggest the safety and efficacy of Daflon in the treatment of varicocele-associated pain. However, these results of the present study must be confirmed by randomized placebo-controlled studies by using different drug doses and durations before making any recommendation for the use of Daflon.

Keywords

Conservative treatment Micronised purified flavonoid fraction Pain Semen analysis Varicocele 

Copyright information

© Springer Science+Business Media, B.V. 2011

Authors and Affiliations

  • Haluk Söylemez
    • 1
  • Süleyman Kiliç
    • 2
  • Murat Atar
    • 1
  • Necmettin Penbegül
    • 1
  • Ahmet Ali Sancaktutar
    • 1
  • Yaşar Bozkurt
    • 1
  1. 1.Department of Urology, Medical FacultyDicle UniversityDiyarbakirTurkey
  2. 2.Department of UrologyPrivate World HospitalBatmanTurkey

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