The association between thyroid hormones and arterial stiffness in peritoneal dialysis patients
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- Tatar, E., Sezis Demirci, M., Kircelli, F. et al. Int Urol Nephrol (2012) 44: 601. doi:10.1007/s11255-011-0034-7
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The association between thyroid hormones and arterial stiffness is unclear. In this study, we investigated, for the first time in a large cohort of euthyroid peritoneal dialysis patients, the relationship between thyroid hormone levels and arterial stiffness.
Fifty-seven patients were enrolled. Serum TSH, free T3 and free T4 levels were measured by chemiluminescence immunoassay method. Pulse wave analysis [augmentation index (AIx) and subendocardial viability ratio (SEVR)] were measured to assess arterial stiffness.
Mean age was 49 ± 12.3 years, and 56.1% were female. Mean TSH, fT3 and fT4 levels were 1.97 ± 0.99 mIU/ml, 2.80 ± 0.42 pg/ml and 1.22 ± 0.16 ng/dl, respectively. Mean AIx and SEVR were 22.3 ± 11.3 and 136 ± 21%, respectively. AIx was negatively correlated with residual urine volume (r = −0.372, P: 0.03) and fT3 levels (r = −0.382, P: 0.005). SEVR was correlated only with TSH level (r = −0.394, P: 0.003). In linear regression analysis adjusted for age, gender, history of diabetes and cardiovascular disease and residual diuresis, fT3 level (t = −3.949, P < 0.001) remained associated with AIx. Only TSH level (t = −2.409, P: 0.02) was related to SEVR.
Low serum fT3 level is associated with arterial stiffness, and high TSH level within the normal range is related to lower SEVR in euthyroid PD patients.