Cofilin-1 in the podocyte: a molecular switch for actin dynamics
- First Online:
- Cite this article as:
- Berger, K. & Moeller, M.J. Int Urol Nephrol (2011) 43: 273. doi:10.1007/s11255-010-9898-1
- 330 Downloads
Summary of key findings
Studies by Garg et al. and Ashworth et al. investigated the functional relevance of a key regulatory protein, cofilin-1, for podocyte actin dynamics (Ashworth et al. in PLos One 5:e12626, 2010; Garg et al. in J Biol Chem 285:22676–22688, 2010). Using different model organisms (zebrafish or transgenic mice), both groups observed a collapse of the glomerular filtration barrier upon inactivation of cofilin-1. In elegant biochemical studies, Garg et al. established that cofilin-1 activity is regulated by nephrin, which is part of the slit diaphragm complex. Two feedback loops stabilize cofilin-1 in the phosphorylated versus dephosphorylated state. The novel findings render cofilin-1 activity as potential diagnostic marker for pathological changes in the podocyte cytoarchitecture.