International Urology and Nephrology

, Volume 44, Issue 1, pp 263–268

Anemia at one year is an independent risk factor of graft survival

  • Luís Gustavo Modelli de Andrade
  • Juliana Maria Gera Abrão
  • Maria Fernanda Cordeiro Carvalho
Nephrology – Original Paper

DOI: 10.1007/s11255-010-9854-0

Cite this article as:
de Andrade, L.G.M., Abrão, J.M.G. & Carvalho, M.F.C. Int Urol Nephrol (2012) 44: 263. doi:10.1007/s11255-010-9854-0

Abstract

Background

Post-transplant anemia is multifactorial and highly prevalent. Some studies have associated anemia with mortality and graft failure. The purpose of this study was to assess whether the presence of anemia at 1 year is an independent risk factor of mortality and graft survival.

Methods

All patients transplanted at a single center who survived at least 1 year after transplantation and showed no graft loss (n = 214) were included. Demographic and clinical data were collected at baseline and at 1 year. Patients were divided into two groups (anemic and nonanemic) based on the presence of anemia (hemoglobin < 130 g/l in men and 120 g/l in women).

Results

Baseline characteristics such as age, gender, type of donor, CKD etiology, rejection, and mismatches were similar in both groups. Creatinine clearance was similar in both anemic and nonanemic groups (69.32 ± 29.8 × 75.69 ± 30.5 ml/mim; P = 0.17). A Kaplan–Meier plot showed significantly poorer death-censored graft survival in the anemic group, P = 0.003. Multivariate analysis revealed that anemic patients had a hazard ratio for the graft loss of 3.85 (95% CI: 1.49–9.96; P = 0.005).

Conclusions

In this study, anemia at 1 year was independently associated with death-censored graft survival and anemic patients were 3.8-fold more likely to lose the graft.

Keywords

Anemia Graft survival Kidney Mortality Transplant 

Copyright information

© Springer Science+Business Media, B.V. 2010

Authors and Affiliations

  • Luís Gustavo Modelli de Andrade
    • 1
  • Juliana Maria Gera Abrão
    • 1
  • Maria Fernanda Cordeiro Carvalho
    • 1
  1. 1.Department of Internal MedicineBotucatu Medical SchoolBotucatuBrazil