Original Article

International Urology and Nephrology

, Volume 40, Issue 2, pp 311-316

First online:

Urinary bladder leiomyosarcoma in adults

  • Apostolos P. LabanarisAffiliated withDepartment of Urology, Martha Maria Medical Center Email author 
  • , Vahudin ZugorAffiliated withDepartment of Urology, University of Erlangen Medical Center
  • , Bernd MeyerAffiliated withDepartment of Urology, Martha Maria Medical Center
  • , Reinhold NützelAffiliated withDepartment of Urology, Martha Maria Medical Center
  • , Stephan HelmusAffiliated withDepartment of Urology, Martha Maria Medical Center
  • , Panagiotis G. LabanarisAffiliated withDepartment of Urology, Interbalkan Medical Center
  • , Reinhard KühnAffiliated withDepartment of Urology, Martha Maria Medical Center

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Non-urothelial neoplasms of the bladder account for fewer than 5% of all bladder tumors. Sarcoma constitutes the most usual mesenchymal malignancy of the bladder, with leiomyosarcomas being the most common type of sarcoma in adults.

Patients and methods

The records of seven patients presenting to two different institutions with bladder leiomyosarcomas between 2003 and 2007 and between 2000 and 2007, respectively, were examined. Cystoscopy, with transurethral resection of the bladder tumor was initially performed in all patients, with leiomyosarcoma being initially diagnosed on the basis of examination of the transurethral specimen.


There were N = 5 men and N = 2 women with a median age of 64.8 years at presentation. All seven patients underwent a definitive surgical procedure. Complete resection with negative surgical margins was achieved in all seven patients (100%). MSKCC stage included 86% of patients with stage 3 (N = 6) and 14% with stage 2 (N = 1). A low-grade tumor was evident in one patient only, with the remaining 86% exhibiting a high-grade tumor.


Leiomyosarcomas of the bladder have always been considered as a highly aggressive entity and little is known about their origin, clinicopathologic presentation, and the survival factors associated with them. Contemporary studies suggest that these tumors may have a better prognosis than once believed. Leiomyosarcomas require aggressive surgical extirpation and, when surgical resection is possible, radical cystectomy with wide margins is the rule and should be performed. Strict adherence to standard surgical technique has resulted in low rates of positive surgical margins and low rates of local tumor recurrence.


Bladder leiomyosarcoma Treatment Prognosis