International Urology and Nephrology

, Volume 39, Issue 4, pp 1227–1233

Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions

  • Mehmet Kanbay
  • Adem Ozkara
  • Yusuf Selcoki
  • Bunyamin Isik
  • Faruk Turgut
  • Nuket Bavbek
  • Ebru Uz
  • Ali Akcay
  • Ramazan Yigitoglu
  • Adrian Covic
Original Article

DOI: 10.1007/s11255-007-9253-3

Cite this article as:
Kanbay, M., Ozkara, A., Selcoki, Y. et al. Int Urol Nephrol (2007) 39: 1227. doi:10.1007/s11255-007-9253-3

Abstract

Background

Hyperuricemia has been associated with the development of hypertension, cardiovascular, and renal disease. However, there is no data about the effect of lowering uric acid level on hypertension, renal function, and proteinuria in patients with glomerular filtration rate (GFR) >60 ml/min. We therefore conducted a prospective study to investigate the benefits of allopurinol treatment in hyperuricemic patients with normal renal function.

Materials and methods

Forty-eight hyperuricemic and 21 normouricemic patients were included in the study. Hyperuricemic patients received 300 mg/day allopurinol for three months. All patients’ serum creatinine level, 24-h urine protein level, glomerular filtration rate, and blood pressure levels were measured at baseline and after three months of treatment.

Results

A total of 59 patients completed the three-month follow-up period of observation. In the allopurinol group, serum uric acid levels, GFR, systolic and diastolic blood pressure, and C-reactive protein (CRP) levels significantly improved (P < 0.05). However, urine protein excretion remained unchanged (P > 0.05). No correlation was observed between changes in GFR and changes in CRP, or blood pressure in the allopurinol group. No significant changes were observed in the control group (P > 0.05).

Conclusion

We bring indirect evidence that hyperuricemia increases blood pressure, and decreases GFR. Hence, management of hyperuricemia may prevent the progression of renal disease, even in patients with normal renal function, suggesting that early treatment with allopurinol should be an important part of the management of chronic kidney disease (CKD) patients. Long-term follow-up studies are warranted to identify the benefits of uric acid management on renal function and hypertension.

Keywords

Uric acidAllopurinolBlood pressureRenal functionProteinuria

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Mehmet Kanbay
    • 1
    • 2
  • Adem Ozkara
    • 3
  • Yusuf Selcoki
    • 4
  • Bunyamin Isik
    • 3
  • Faruk Turgut
    • 2
  • Nuket Bavbek
    • 2
  • Ebru Uz
    • 2
  • Ali Akcay
    • 2
  • Ramazan Yigitoglu
    • 5
  • Adrian Covic
    • 6
  1. 1.AnkaraTurkey
  2. 2.Department of Internal Medicine, Section of NephrologyFatih University School of MedicineAnkaraTurkey
  3. 3.Department of Family MedicineFatih University School of MedicineAnkaraTurkey
  4. 4.Department of CardiologyFatih University School of MedicineAnkaraTurkey
  5. 5.Department of BiochemistryFatih University School of MedicineAnkaraTurkey
  6. 6.Department of Nephrology Clinic and Dialysis and Transplantation Center“C. I. PARHON” University HospitalIasiRomania