International Urology and Nephrology

, Volume 39, Issue 1, pp 209–214

Significance of radical cystectomy for bladder cancer in patients over 80 years old

  • Kazuki Yamanaka
  • Hideaki Miyake
  • Isao Hara
  • Taka-aki Inoue
  • Masato Fujisawa
Original Paper

DOI: 10.1007/s11255-006-9122-5

Cite this article as:
Yamanaka, K., Miyake, H., Hara, I. et al. Int Urol Nephrol (2007) 39: 209. doi:10.1007/s11255-006-9122-5

Abstract

Objectives

The objective of this study was to evaluate the usefulness of radical cystectomy for bladder cancer in elderly patients.

Materials and methods

This study included 72 patients aged ≥80 years (group A) who underwent radical cystectomy and urinary diversion between January 1995 and December 2003, and the clinical outcome of these patients were compared with those of 557 patients aged <80 years (group B) undergoing radical cystectomy during the same period as group A.

Results

As the procedure for urinary diversion, ureterocutaneostomy was most frequently performed in group A (87.5%), while neobladder creation was most common in group B (43.8%). Despite the absence of significant differences in tumor grade and incidence of lymph node metastasis between these two groups, pathological stage in group A was significantly greater than that in group B. The perioperative mortality rate in group A was significantly higher than that in group B, whereas the incidences of both early and late postoperative complications in group A were similar to those in group B. Cancer-specific survival in group A was significantly lower than that in group B; however, among patients with disease ≤pT2, there was no significant difference in cancer-specific survival between these two groups.

Conclusions

These findings suggest that an aggressive surgical approach may be an optimal therapeutic strategy for properly selected elderly patients who require definitive therapy for locally invasive bladder cancer, particularly in those with disease ≤pT2.

Keywords

Radical cystectomyBladder cancerElderly patientsUrinary diversionPrognosis

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Kazuki Yamanaka
    • 1
  • Hideaki Miyake
    • 1
  • Isao Hara
    • 1
  • Taka-aki Inoue
    • 2
  • Masato Fujisawa
    • 1
  1. 1.Division of UrologyKobe University Graduate School of medicineChuo-kuJapan
  2. 2.Department of UrologyHyogo Medical Center for AdultsAkashiJapan