International Urology and Nephrology

, Volume 39, Issue 3, pp 879–886

A prospective study of the efficacy of Serenoa repens, Tamsulosin, and Serenoa repens plus Tamsulosin treatment for patients with benign prostate hyperplasia

Authors

    • Department of UrologyOncology Education and Research Hospital
  • M. Cemil Uygur
    • Department of UrologyOncology Education and Research Hospital
Original Paper

DOI: 10.1007/s11255-006-9106-5

Cite this article as:
Hızlı, F. & Uygur, M.C. Int Urol Nephrol (2007) 39: 879. doi:10.1007/s11255-006-9106-5

Abstract

Introduction

Increasing attention has been focused on the use of phytotherapeutic agents to alleviate the symptoms of benign prostatic hyperplasia (BPH) in recent times. The best described and studied phytotherapeutic agent is Serenoa repens (SR).

Materials and methods

This prospective study was designed to have 3 arms including SR 320 mg per day (N = 20), Tamsulosin (TAM) 0.4 mg per day (N = 20) and SR + TAM (N = 20) to reveal the superiority or equivalence between these treatment regimens in BPH.

Results

The groups were not statistically different with regard to increase in maximal urinary flow rate (Qmax) and decrease in International Prostate Symptom Score (I-PSS) (P > 0.05). No adverse effect was detected in SR therapy group.

Conclusion

Treatment of BPH by both SR and TAM seems to be effective alone. None of them had superiority to another and additionally, combined therapy (SR + TAM) does not provide extra benefits. Furthermore SR is a well-tolerated agent that can be used alternatively in the treatment of LUTS due to BPH.

Keywords

Serenoa repensBPHTamsulosinTreatment

Copyright information

© Springer Science+Business Media, Inc. 2006