International Urology and Nephrology

, Volume 37, Issue 3, pp 485–492

The Prognostic Importance of E-cadherin and p53 Gene Expression in Transitional Bladder Carcinoma Patients

  • Arisan Serdar
  • Caskurlu Turhan
  • Guney Soner
  • Sonmez Nurettin Cem
  • Keles Bayram
  • Buyuktuncer Elif Damla
  • Ergenekon Erbil
Article

DOI: 10.1007/s11255-005-0919-4

Cite this article as:
Serdar, A., Turhan, C., Soner, G. et al. Int Urol Nephrol (2005) 37: 485. doi:10.1007/s11255-005-0919-4

Abstract

Objective: The clinical course of transitional cell carcinoma is highly variable. The determination of sensitive prognostic factors for transitional cell carcinoma is very important. Therefore e-cadherin and p53 immunohistochemical activity can be used with other prognostic factors. Methods: The study comprised with 61 (4 women and 57 men) selected patients who had transitional cell carcinoma. Paraffin embedded tissue sections were investigated immunohistochemically for e-cadherin normal staining and p53 over expression. Results: It is seen that when grade and stages of illness increased normal staining of e-cadherin decreased and p53 over expressed. Abnormal e-cadherin was significantly associated with disease recurrence (P < 0.001), disease progression (P < 0.001) and bladder specific survival. p53 differentiation was not significant for disease recurrence (P > 0.05) inverse to prognosis of illness. Transurethral resectomy and BCG treatments were not effected e-cadherin and p53 activity within the groups statistically. Conclusion: Significant differences can be helpful to investigate patients more detailed pathologically. These expression rates in different type of transitional cell carcinoma patients may represent a biologically more aggressive cancer, requiring early definitive therapy. This hypothesis should be evaluated in larger studies and prospective clinical trials.

Keywords

E-cadherinsImmunohistochemistryp53PrognosisTCCTumor markers

Copyright information

© Springer 2005

Authors and Affiliations

  • Arisan Serdar
    • 1
  • Caskurlu Turhan
    • 1
  • Guney Soner
    • 1
  • Sonmez Nurettin Cem
    • 1
  • Keles Bayram
    • 1
  • Buyuktuncer Elif Damla
    • 2
    • 3
  • Ergenekon Erbil
    • 1
  1. 1.Sisli Etfal Research and Training HospitalIst Urology ClinicsIstanbulTurkey
  2. 2.Molecular Biology and Genetics DepartmentHalic UniversityFindikzade-IstanbulTurkey
  3. 3.Cancer Biology and Oncology Department (CRB562), Sidney Kimmel Cancer Center, School of Medicine East Baltimore CampusJohns Hopkins UniversityBaltimoreUSA