Transgenic Research

, Volume 16, Issue 3, pp 315–332

Production of vaccines and therapeutic antibodies for veterinary applications in transgenic plants: an overview

  • Doreen Manuela Floss
  • Dieter Falkenburg
  • Udo Conrad
Review

DOI: 10.1007/s11248-007-9095-x

Cite this article as:
Floss, D.M., Falkenburg, D. & Conrad, U. Transgenic Res (2007) 16: 315. doi:10.1007/s11248-007-9095-x

Abstract

During the past two decades, antibodies, antibody derivatives and vaccines have been developed for therapeutic and diagnostic applications in human and veterinary medicine. Numerous species of dicot and monocot plants have been genetically modified to produce antibodies or vaccines, and a number of diverse transformation methods and strategies to enhance the accumulation of the pharmaceutical proteins are now available. Veterinary applications are the specific focus of this article, in particular for pathogenic viruses, bacteria and eukaryotic parasites. We focus on the advantages and remaining challenges of plant-based therapeutic proteins for veterinary applications with emphasis on expression platforms, technologies and economic considerations.

Keywords

Molecular pharmingPlant-based vaccinesTherapeutic antibodiesTransgenic plantsVeterinary medicine

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Doreen Manuela Floss
    • 1
  • Dieter Falkenburg
    • 2
  • Udo Conrad
    • 1
  1. 1.Leibniz Institute of Plant Genetics and Crop Plant Research (IPK)GaterslebenGermany
  2. 2.Novoplant GmbHGaterslebenGermany