Journal of Thrombosis and Thrombolysis

, Volume 37, Issue 3, pp 362–371

Antiplatelet therapy in prevention of cardio- and venous thromboembolic events

  • Steven R. Steinhubl
  • John W. Eikelboom
  • Elaine M. Hylek
  • Harold L. Dauerman
  • Susan S. Smyth
  • Richard C. Becker
Article

DOI: 10.1007/s11239-013-1023-8

Cite this article as:
Steinhubl, S.R., Eikelboom, J.W., Hylek, E.M. et al. J Thromb Thrombolysis (2014) 37: 362. doi:10.1007/s11239-013-1023-8
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Abstract

The contribution of platelets in the pathophysiology of low-shear thrombosis—specifically, in atrial fibrillation (AF) and venous thromboembolic events (VTE)—remains less clear than for arterial thrombosis. AF itself appears to lead to platelet activation, offering a potential target for aspirin and other antiplatelet agents. Randomized trial results suggest a small benefit of aspirin over placebo, and of dual antiplatelet therapy (aspirin plus clopidogrel) over aspirin alone, for prevention of cardioembolic events in AF. Antiplatelet therapy thus can represent an option for patients with AF who are unsuitable for therapy with warfarin or novel oral anticoagulant agents. For VTE, the rationale for antiplatelet therapy reflects the venous response to disrupted blood flow—interactions among monocytes, neutrophil extracellular traps, and platelets. Early randomized trials generally showed poorer performance of aspirin relative to heparins and danaparoid sodium in prevention of VTE. However, results from large placebo- and dalteparin-controlled randomized trials have spurred changes in the most recent practice guidelines—aspirin is now recommended after major orthopedic surgery for patients who cannot receive other antithrombotic therapies.

Keywords

Platelets Fibrillation Thrombosis 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Steven R. Steinhubl
    • 1
  • John W. Eikelboom
    • 2
  • Elaine M. Hylek
    • 3
  • Harold L. Dauerman
    • 4
  • Susan S. Smyth
    • 5
  • Richard C. Becker
    • 6
  1. 1.Scripps Translational Science InstituteLa JollaUSA
  2. 2.McMaster UniversityHamiltonCanada
  3. 3.Thrombosis Clinic and Anticoagulation ServiceBoston UniversityBostonUSA
  4. 4.University of VermontBurlingtonUSA
  5. 5.Department of Medicine, Physiology, and PharmacologyUniversity of Kentucky and Veterans Affairs Medical CenterLexingtonUSA
  6. 6.Division of Cardiovascular Health and Disease, Department of Internal MedicineUniversity of Cincinnati College of MedicineCincinnatiUSA

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