Journal of Thrombosis and Thrombolysis

, Volume 35, Issue 3, pp 352–358

Sickle cell disease and venous thromboembolism: what the anticoagulation expert needs to know

  • Rakhi P. Naik
  • Michael B. Streiff
  • Sophie Lanzkron
Article

DOI: 10.1007/s11239-013-0895-y

Cite this article as:
Naik, R.P., Streiff, M.B. & Lanzkron, S. J Thromb Thrombolysis (2013) 35: 352. doi:10.1007/s11239-013-0895-y

Abstract

Venous thromboembolism (VTE) is common in patients with sickle cell disease (SCD). The etiology of increased risk of VTE in SCD patients is multifactorial and is related to both traditional factors and SCD-specific factors. Traditional risk factors such as central venous catheters, frequent hospitalization, orthopedic surgeries for avascular necrosis, and pregnancy may lead to increased incidence of VTE in the SCD population. In addition, SCD itself appears to be a hypercoagulable state, and many SCD-specific factors such as thrombophilic defects, genotype and splenectomy may modify the risk of VTE. SCD complications such as acute chest syndrome and pulmonary hypertension may also be related to VTE. Anticoagulation experts should be aware of these factors to help inform prophylaxis and treatment decisions.

Keywords

Sickle cell diseaseVenous thromboembolismDeep venous thrombosisPulmonary embolismAnticoagulation

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Rakhi P. Naik
    • 1
  • Michael B. Streiff
    • 1
  • Sophie Lanzkron
    • 1
  1. 1.Division of Hematology, Department of MedicineJohns Hopkins UniversityBaltimoreUSA