Journal of Thrombosis and Thrombolysis

, Volume 36, Issue 4, pp 394–401

Meta-analyses of four eosinophil related gene variants in coronary heart disease

  • Jiangfang Lian
  • Yi Huang
  • R. Stephanie Huang
  • Limin Xu
  • Yanping Le
  • Xi Yang
  • Weifeng Xu
  • Xiaoyan Huang
  • Meng Ye
  • Jianqing Zhou
  • Shiwei Duan
Article

DOI: 10.1007/s11239-012-0862-z

Cite this article as:
Lian, J., Huang, Y., Huang, R.S. et al. J Thromb Thrombolysis (2013) 36: 394. doi:10.1007/s11239-012-0862-z

Abstract

The goal of our study is to assess the contribution of four eosinophil related gene variants (rs12619285, rs1420101, rs3184504 and rs4143832) to the risk of coronary heart disease (CHD). We conducted four meta-analyses of studies examining the association between four eosinophil related gene variants and the risk of CHD. A systematic search was conducted using MEDLINE, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI), Wanfang Chinese Periodical. A case–control study was conducted between 162 CHD cases and 119 non-CHD controls to explore their contribution to CHD. For rs3184504 of SH2B3 gene, the meta-analysis was performed among 19 study stages among 94,555 participants. Significant association between rs3184504 and CHD risk was observed in European and South Asian populations (OR = 1.13, 95 % CI = 1.10–1.16, p < 0.0001, fixed-effect method). For the other SNPs (rs12619285, rs1420101, and rs4143832), we combined our case–control data with the previous studies and found no association of them with the risk of CHD. No significant contribution of the four genetic variants to CHD was observed in Han Chinese (p > 0.05). In conclusion, our results supported a significant association between rs3184504 of SH2B3 gene and the risk of CHD in Europeans and South Asians, although we were unable to observe association between the four variants and the risk of CHD in Han Chinese.

Keywords

Coronary heart diseaseGenetic variantSH2B3IKZF2IL1RL

Abbreviations

SNP

Single nucleotide polymorphism

CAC

Coronary artery calcification

CHD

Coronary heart disease

MI

Myocardial infarction

HWE

Hardy–Weinberg equilibrium

Supplementary material

11239_2012_862_MOESM1_ESM.doc (136 kb)
Supplementary material 1 (DOC 136 kb)

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jiangfang Lian
    • 1
  • Yi Huang
    • 2
  • R. Stephanie Huang
    • 3
  • Limin Xu
    • 2
  • Yanping Le
    • 2
  • Xi Yang
    • 1
  • Weifeng Xu
    • 1
  • Xiaoyan Huang
    • 1
  • Meng Ye
    • 2
  • Jianqing Zhou
    • 1
  • Shiwei Duan
    • 2
  1. 1.Ningbo Medical CenterLihuili Hospital, Ningbo UniversityNingboChina
  2. 2.The Affiliated Hospital, School of Medicine, Ningbo UniversityNingboChina
  3. 3.Department of MedicineUniversity of ChicagoChicagoUSA