Journal of Thrombosis and Thrombolysis

, Volume 36, Issue 3, pp 352–354

Successful liver transplantation in a patient with splanchnic vein thrombosis and pulmonary embolism due to polycythemia vera with Jak2v617f mutation and heparin-induced thrombocytopenia

  • Emanuela Biagioni
  • Paola Pedrazzi
  • Marco Marietta
  • Fabrizio Di Benedetto
  • Erica Villa
  • Mario Luppi
  • Massimo Girardis
Article

DOI: 10.1007/s11239-012-0832-5

Cite this article as:
Biagioni, E., Pedrazzi, P., Marietta, M. et al. J Thromb Thrombolysis (2013) 36: 352. doi:10.1007/s11239-012-0832-5

Abstract

Heparin-induced thrombocytopenia (HIT) is a rare complication of heparin treatment resulting in a severe acquired thrombophilic condition with an associated mortality of about 10 %. We report the first case of successful urgent liver transplantation (LT) in a patient with end-stage liver disease due to a Budd–Chiari syndrome, portal vein thrombosis and pulmonary embolism due to acquired thrombophilia associated to polycythemia vera carrying JAK2V617F gene mutation and HIT in the acute phase. Lepirudin was used to provide anticoagulation in the LT perioperative period that was performed without haemorrhagic and thrombotic complications despite the donor received heparin during liver explantation.

Keywords

Heparin-induced thrombocytopeniaLiver transplantationSplanchnic vein thrombosisPolycythemia veraLepirudinJAK2V617F mutation

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Emanuela Biagioni
    • 1
  • Paola Pedrazzi
    • 2
  • Marco Marietta
    • 2
  • Fabrizio Di Benedetto
    • 3
  • Erica Villa
    • 4
  • Mario Luppi
    • 2
  • Massimo Girardis
    • 1
  1. 1.Surgical ICU, Anesthesia and Intensive Care DepartmentUniversity Hospital of ModenaModenaItaly
  2. 2.Haemostasis and Thrombosis Unit, Department of HematologyUniversity Hospital of ModenaModenaItaly
  3. 3.Liver Transplantation Surgical Unit, Department of TransplantationUniversity Hospital of ModenaModenaItaly
  4. 4.Gastroenterology Unit, Department of MedicineUniversity Hospital of ModenaModenaItaly