Journal of Thrombosis and Thrombolysis

, Volume 34, Issue 3, pp 335–346

Biomarkers of deep venous thrombosis

  • Huacheng Hou
  • Zhijuan Ge
  • Pu Ying
  • Jin Dai
  • Dongquan Shi
  • Zhihong Xu
  • Dongyang Chen
  • Qing Jiang
Article

DOI: 10.1007/s11239-012-0721-y

Cite this article as:
Hou, H., Ge, Z., Ying, P. et al. J Thromb Thrombolysis (2012) 34: 335. doi:10.1007/s11239-012-0721-y

Abstract

Deep venous thrombosis (DVT), which is associated with pulmonary embolism, is a fatal disease because of its high morbidity and mortality in outpatients and inpatients, especially in hospitalized patients. At the same time, lack of subjective clinical symptoms and objective clinical signs makes the diagnosis complicated. Historically, the primarily imaging modalities, including duplex ultrasound, helical CT scans, and venography, establish the diagnosis of DVT. Currently, both imaging modalities and serology are utilized. These plasma molecules are regarded as the biomarkers of DVT including D-dimer, P-selectin, Factor VIII, thrombin generation, inflammatory cytokines, microparticles, fibrin monomer, leukocyte count and so on. This brief review is used to analyze the contribution of the biomarkers to diagnosis and guidance of therapy for DVT.

Keywords

DVT D-dimer P-selectin FVIII TG Inflammatory cytokines MPs FM Leukocyte count 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Huacheng Hou
    • 1
    • 2
  • Zhijuan Ge
    • 2
  • Pu Ying
    • 2
  • Jin Dai
    • 1
  • Dongquan Shi
    • 1
  • Zhihong Xu
    • 1
  • Dongyang Chen
    • 1
  • Qing Jiang
    • 1
  1. 1.The Center of Diagnosis and Treatment for Joint Disease, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing UniversityNanjingPeople’s Republic of China
  2. 2.Medical School of Nanjing UniversityNanjingPeople’s Republic of China

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