Journal of Thrombosis and Thrombolysis

, Volume 34, Issue 1, pp 65–72

Intracoronary versus intravenous high-dose bolus plus maintenance administration of tirofiban in patients undergoing primary percutaneous coronary intervention for acute ST elevation myocardial infarction

  • Basar Candemir
  • Mustafa Kilickap
  • Ozgur Ulas Ozcan
  • Cansin Tulunay Kaya
  • Menekse Gerede
  • Aydan Ongun Ozdemir
  • Cagdas Ozdol
  • Deniz Kumbasar
  • Cetin Erol
Article

DOI: 10.1007/s11239-012-0685-y

Cite this article as:
Candemir, B., Kilickap, M., Ozcan, O.U. et al. J Thromb Thrombolysis (2012) 34: 65. doi:10.1007/s11239-012-0685-y

Abstract

We aimed to examine whether intracoronary high-dose bolus of tirofiban plus maintenance would result in improved clinical outcome in STEMI patients undergoing primary PCI in this pilot trial. A total of 56 patients were enrolled to receive either intracoronary high-dose bolus plus maintenance (n = 34) or intravenous high-dose bolus plus maintenance (n = 22) of tirofiban. Pre and post intervention TIMI flow grades, myocardial blush grades, peak CKMB and troponin levels, time to peak CKMB and troponin, time to 50% ST resolution and major composite adverse cardiac event rates at 30 days were recorded. Although incidence of major adverse cardiac events was not different, post intervention TIMI flow and TIMI blush grades, peak CKMB and troponin levels, and time to peak CKMB and time to peak troponin were significantly different, favoring intracoronary strategy. In conclusion, this regimen improved myocardial reperfusion and coronary flow, and reduced myocardial necrosis, but failed to improve clinical outcomes at 30 days.

Keywords

Glycoprotein 2b/3a inhibitors Coronary artery disease Acute coronary syndrome ST elevation myocardial infarction 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Basar Candemir
    • 1
  • Mustafa Kilickap
    • 1
  • Ozgur Ulas Ozcan
    • 1
  • Cansin Tulunay Kaya
    • 1
  • Menekse Gerede
    • 1
  • Aydan Ongun Ozdemir
    • 1
  • Cagdas Ozdol
    • 1
  • Deniz Kumbasar
    • 1
  • Cetin Erol
    • 1
  1. 1.Cardiology DepartmentAnkara UniversityAnkaraTurkey

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