Journal of Thrombosis and Thrombolysis

, Volume 28, Issue 4, pp 489–495

Update on phase II studies of erythropoietin in acute myocardial infarction. Rationale and design of Exogenous erythroPoietin in Acute Myocardial Infarction: New Outlook aNd Dose Association Study (EPAMINONDAS)

Authors

    • Institute of Cardiology, Department of Cardiovascular Medicine“A. Gemelli” University Hospital
  • Luciano Agati
    • Department of Cardiology, 1st Faculty“La Sapienza” University
  • Elena Conti
    • Department of Cardiology, 2nd Faculty“La Sapienza” University
  • Eleonora Santucci
    • Institute of Cardiology, Department of Cardiovascular Medicine“A. Gemelli” University Hospital
  • Teresa Rio
    • Institute of Cardiology, Department of Cardiovascular Medicine“A. Gemelli” University Hospital
  • Federica Tarantino
    • Institute of Cardiology, Department of Cardiovascular Medicine“A. Gemelli” University Hospital
  • Luigi Natale
    • Department of Radiology“A. Gemelli” University Hospital
  • Daniele Berardi
    • Department of Cardiology, 1st Faculty“La Sapienza” University
  • Antonella Mattatelli
    • Department of Cardiology, 1st Faculty“La Sapienza” University
  • Beatrice Musumeci
    • Department of Cardiology, 2nd Faculty“La Sapienza” University
  • Lorenzo Bonomo
    • Department of Radiology“A. Gemelli” University Hospital
  • Massimo Volpe
    • Department of Cardiology, 2nd Faculty“La Sapienza” University
    • IRCCS, Neuromed
  • Filippo Crea
    • Institute of Cardiology, Department of Cardiovascular Medicine“A. Gemelli” University Hospital
  • Camillo Autore
    • Department of Cardiology, 2nd Faculty“La Sapienza” University
Article

DOI: 10.1007/s11239-009-0363-x

Cite this article as:
Andreotti, F., Agati, L., Conti, E. et al. J Thromb Thrombolysis (2009) 28: 489. doi:10.1007/s11239-009-0363-x

Abstract

Erythropoietin (Epo) is a hematopoietic hormone produced mainly by the kidneys in response to hypoxia. Recent acquisitions in the fields of hematology, neurology, cardiology, and experimental medicine show cytoprotective, angiogenetic and antinflammatory effects of Epo. Exogenous erythroPoietin in Acute Myocardial Infarction: New Outlook aNd Dose Association Study (EPAMINONDAS, EudraCTno. 200500485386) is one of four ongoing randomized controlled trials, each testing the effects of Epo in ≥100 patients with STEMI. EPAMINONDAS is a multicenter, prospective, double-blind, placebo-controlled, dose-finding study assessing intravenous moderate doses of human recombinant Epo (epoietin-α, 100 or 200 IU/kg/die) versus placebo, given on the first 3 days, in 102 patients with first ST-segment elevation myocardial infarction. Initial dosing is within 12 h of primary percutaneous coronary revascularization. The primary endpoint is infarct size, quantified by CK-MB time–concentration curve, left ventricular wall motion score index, and pattern of contrast-enhanced magnetic resonance imaging. Secondary endpoints are ischemic recurrences, ventricular remodelling, and safety events, assessed in-hospital and at 12 months’ follow-up. The results of current phase II studies will help define the safety/efficacy profile of Epo for patients with STEMI.

Keywords

Human recombinant erythropoietinST-segment elevation myocardial infarctionInfarct sizePrimary PCI

Copyright information

© Springer Science+Business Media, LLC 2009