Journal of Thrombosis and Thrombolysis

, Volume 27, Issue 1, pp 57–67

Transfusion associated microchimerism: a heretofore little recognized complication following transfusion

Authors

  • Vijayalakshmi Kunadian
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Cafer Zorkun
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • William J. Gibson
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Navin Nethala
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Caitlin Harrigan
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Alexandra M. Palmer
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Katherine J. Ogando
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Leah H. Biller
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Erin E. Lord
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Scott P. Williams
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Michelle E. Lew
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Lauren N. Ciaglo
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Jacqueline L. Buros
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
  • Susan J. Marble
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
    • Cardiovascular Division, Department of MedicineBeth Israel Deaconess Medical Center, Harvard Medical School
Article

DOI: 10.1007/s11239-008-0268-0

Cite this article as:
Kunadian, V., Zorkun, C., Gibson, W.J. et al. J Thromb Thrombolysis (2009) 27: 57. doi:10.1007/s11239-008-0268-0

Abstract

Potent antiplatelet and antithrombotic agents have significantly reduced mortality in the setting of acute coronary syndromes and percutaneous coronary intervention. However these agents are associated with increased bleeding which is in turn associated with adverse clinical outcomes. In many centers, transfusion is often used to correct for blood loss. Blood transfusion in the setting of acute coronary syndrome has been associated with adverse clinical outcomes including increased mortality. Transfusion associated microchimerism (TA-MC) is a newly recognized complication of blood transfusion. There is engraftment of the donor’s hematopoietic stem cells in patients who then develop microchimerism. This article discusses the association of bleeding/blood transfusion with adverse outcomes and the potential role of TA-MC in clinical outcomes.

Keywords

BleedingTransfusionMortalityChimerismMyocardial infarction

Abbreviations

ACS

Acute coronary syndrome

ACUITY

Acute catheterization and urgent intervention triage strategy

ASSENT

Assessment of the safety and efficacy of a new thrombolytic regimen

CABG

Coronary artery bypass surgery

CLARITY

Clopidogrel as adjunctive reperfusion therapy

COMMIT

Clopidogrel and metoprolol in myocardial infarction trial

CURE

Clopidogrel in unstable angina to prevent recurrent events trial

EPIC

Evaluation of c7E3 for prevention of ischemic complications

EPILOG

Evaluation in PTCA to improve long-term outcome with abciximab GP IIb/IIIa blockade

ESPRIT

Enhanced suppression of the platelet IIb/IIIa receptor with integrilin therapy

ESSENCE

Efficacy and safety of subcutaneous enoxaparin in non-Q-wave coronary events trial

EXTRACT

Enoxaparin and thrombolysis reperfusion for acute myocardial infarction treatment

GRACE

Global registry of acute coronary events

GUSTO

Global utilization of streptokinase to open occluded arteries

GvHD

Graft versus host disease

Hb

Hemoglobin

HERO

Hirulog and early reperfusion or occlusion

HIV

Human immunodeficiency virus

HORIZONS

Harmonizing outcomes with revascularization and stents

IL

Interleukin

MI

Myocardial infarction

NSTEMI

Non ST elevation myocardial infarction

OASIS

Organization to assess strategies for ischemic syndromes

PCI

Percutaneous coronary intervention

PCR

Polymerase chain reaction

PURSUIT

Platelet glycoprotein IIB/IIIA in unstable angina: receptor suppression using integrilin therapy

REPLACE

Randomized evaluation in PCI linking angiomax to reduced clinical events

STEEPLE

Safety and efficacy of enoxaparin in PCI patients, an international randomized evaluation

STEMI

ST elevation myocardial infarction

SYNERGY

Superior yield of the new strategy of enoxaparin, revascularization and glycoprotein IIb/IIIa inhibitors trial

TAMC

Transfusion associated microchimerism

TIMI

Thrombolysis in myocardial infarction

TNF

Tumor necrosis factor

TRITON

Trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-thrombolysis in myocardial infarction-38

Copyright information

© Springer Science+Business Media, LLC 2008