Journal of Thrombosis and Thrombolysis

, Volume 19, Issue 1, pp 11–19

Identification, Diagnosis and Treatment of Heparin-induced Thrombocytopenia and Thrombosis: A Registry of Prolonged Heparin Use and Thrombocytopenia among Hospitalized Patients with and without Cardiovascular Disease

The Complication After Thrombocytopenia Caused by Heparin (CATCH) Registry Steering Committee
  • E. Magnus Ohman
  • Christopher B. Granger
  • Lawrence Rice
  • Charles S. Abrams
  • Richard C. Becker
  • Peter B. Berger
  • Neal S. Kleiman
  • David Moliterno
  • Stephan Moll
  • Jo E. Rodgers
  • Stephen S. Steinhubl
  • Victor F. Tapson
  • Peter Sinnaeve
  • Kevin J. Anstrom
Article

DOI: 10.1007/s11239-005-0850-7

Cite this article as:
Ohman, E.M., Granger, C.B., Rice, L. et al. J Thromb Thrombolysis (2005) 19: 11. doi:10.1007/s11239-005-0850-7

Abstract

Background: Heparin-induced thrombocytopenia (HIT) is estimated to occur in 1–5% of all patients receiving heparin, and 25–50% of such cases develop heparin-induced thrombocytopenia with thrombosis (HITT) A conservative estimate based only on cardiovascular patients suggests that in the United States approximately 100,000 patients develop thrombocytopenia, and 25–50,000 develop HITT annually. Both HIT and HITT are associated with high morbidity and mortality and represent substantial worldwide public health concerns.

Registry Design: The objective of the Complication After Thrombocytopenia Caused by Heparin (CATCH) Registry is to identify the incidence of HIT and/or HITT in patients treated with systemic heparin (unfractionated or low molecular weight heparin) in contemporary practice. Additional objectives include to: (1) provide a comprehensive database of patients with suspected HIT or HITT, (2) monitor and define clinical events, including thrombocytopenia, thrombosis, and mortality among patients treated with prolonged (> 96 hours) heparin, (3) describe the incidence and outcomes of HIT and HITT in patients who are treated with heparin and who develop thrombocytopenia in the Coronary Care Unit setting, and (4) document and characterize current diagnostic and therapeutic strategies of suspected HIT. The unblinded registry will record approximately 5,000 patients at 60–80 US hospitals with either prolonged systemic heparin administration or thrombocytopenia and those with suspected HIT or HITT. Enrollment began in the first quarter 2003 and was completed at the end of 2004.

Implications: The registry will provide valuable insights to the incidence and consequences of HIT and HITT that will enable improvements in diagnosis and treatment.

heparinthrombosisthrombocytopeniaregistry

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • E. Magnus Ohman
    • 1
  • Christopher B. Granger
    • 2
  • Lawrence Rice
    • 3
  • Charles S. Abrams
    • 4
  • Richard C. Becker
    • 2
  • Peter B. Berger
    • 2
  • Neal S. Kleiman
    • 3
  • David Moliterno
    • 5
  • Stephan Moll
    • 1
  • Jo E. Rodgers
    • 1
  • Stephen S. Steinhubl
    • 5
  • Victor F. Tapson
    • 2
  • Peter Sinnaeve
    • 2
  • Kevin J. Anstrom
    • 2
  1. 1.Division of Cardiology, Division of Hematology, and School of PharmacyUniversity of North CarolinaChapel Hill
  2. 2.Division of Cardiology, Division of Pulmonary Medicine and Duke Clinical Research InstituteDuke University Medical CenterDurham
  3. 3.Hematology-Oncology Section and Section of Cardiology, Baylor College of Medicine and Methodist Hospital, Houston, TX; 4Hematology/Oncology DivisionUniversity of Pennsylvania School of MedicinePhiladelphia
  4. 4.Division of Cardiovascular MedicineUniversity of KentuckyLexington
  5. 5.Division of CardiologyUNC-Chapel HillChapel Hill