Structural Chemistry

, Volume 22, Issue 1, pp 161–166

Synthesis and NMR elucidation of homoisoflavanone analogues

Authors

  • Mahidansha Shaikh
    • School of ChemistryUniversity of KwaZulu-Natal
    • School of Pharmacy and PharmacologyUniversity of KwaZulu-Natal
  • Katja Petzold
    • School of ChemistryUniversity of KwaZulu-Natal
  • Hendrik G. Kruger
    • School of ChemistryUniversity of KwaZulu-Natal
    • School of Pharmacy and PharmacologyUniversity of KwaZulu-Natal
Original Research

DOI: 10.1007/s11224-010-9703-x

Cite this article as:
Shaikh, M., Petzold, K., Kruger, H.G. et al. Struct Chem (2011) 22: 161. doi:10.1007/s11224-010-9703-x

Abstract

A series of five homoisoflavanone analogues have been synthesized from the corresponding 3,5-methoxy phenols via chroman-4-one in three steps. The complete NMR elucidation of these homoisoflavanone analogues is reported. The use of 2D NMR techniques (COSY, NOESY, HSQC and HMBC) proved to be very useful tools in the elucidation of homoisoflavanone analogues. The homoisoflavanone analogues exhibit an AA′BB′ spin pattern in the ring B of the homoisoflavanone. These homoisoflavanone analogues are potential antifungal and anti-inflammatory agents.

Keywords

HomoisoflavanoneSynthesisAnti-inflammatoryAntifungal2D NMR

Supplementary material

11224_2010_9703_MOESM1_ESM.pdf (3.1 mb)
Supplementary material 1 (PDF 3152 kb)

Copyright information

© Springer Science+Business Media, LLC 2010