Synthesis and NMR elucidation of homoisoflavanone analogues
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- Shaikh, M., Petzold, K., Kruger, H.G. et al. Struct Chem (2011) 22: 161. doi:10.1007/s11224-010-9703-x
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A series of five homoisoflavanone analogues have been synthesized from the corresponding 3,5-methoxy phenols via chroman-4-one in three steps. The complete NMR elucidation of these homoisoflavanone analogues is reported. The use of 2D NMR techniques (COSY, NOESY, HSQC and HMBC) proved to be very useful tools in the elucidation of homoisoflavanone analogues. The homoisoflavanone analogues exhibit an AA′BB′ spin pattern in the ring B of the homoisoflavanone. These homoisoflavanone analogues are potential antifungal and anti-inflammatory agents.