, Volume 17, Issue 1, pp 161-162
Date: 12 May 2006

Köhler’s Invention Klaus Eichmann (Max-Planck-Institut für Immunbiologie, Freiburg, Germany), Birkhäuser Verlag, Basel. 2005. 223 pp. USD 65.95; EUR 51.36. ISBN 3-7643-7173-0

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Fig. 1
César Milstein and Georges Köhler in 1979 during an international meeting in Kenya (photograph by Celia Milstein, courtesy of the late César Milstein, from I. Hargittai, Candid Science: Conversations with Famous Biomedical Scientists, Imperial College Press, London, 2002)

Georges Köhler (1946–1995) was a co-inventor (with César Milstein, 1927–2002) of a technique for generating monoclonal antibodies. They produced B-cell hybridoma that continuously secretes monoclonal antibody, which has predetermined specificity. Monoclonal antibodies have found

wide applications in basic research, medicine, and biotechnology. The joint invention was made in Milstein’s laboratory at the Laboratory of Molecular Biology (LMB) of the Medical Research Council in Cambridge, England, where Köhler was a postdoctoral researcher. Eichmann’s book is much stronger and more detailed in the science of monoclonal antibodies and related areas than in presenting Köhler as a person. Yet the scarce information h ...