Statistics and Computing

, Volume 16, Issue 3, pp 239–249

A Markov Chain Monte Carlo version of the genetic algorithm Differential Evolution: easy Bayesian computing for real parameter spaces


DOI: 10.1007/s11222-006-8769-1

Cite this article as:
Braak, C.J.F.T. Stat Comput (2006) 16: 239. doi:10.1007/s11222-006-8769-1


Differential Evolution (DE) is a simple genetic algorithm for numerical optimization in real parameter spaces. In a statistical context one would not just want the optimum but also its uncertainty. The uncertainty distribution can be obtained by a Bayesian analysis (after specifying prior and likelihood) using Markov Chain Monte Carlo (MCMC) simulation. This paper integrates the essential ideas of DE and MCMC, resulting in Differential Evolution Markov Chain (DE-MC). DE-MC is a population MCMC algorithm, in which multiple chains are run in parallel. DE-MC solves an important problem in MCMC, namely that of choosing an appropriate scale and orientation for the jumping distribution. In DE-MC the jumps are simply a fixed multiple of the differences of two random parameter vectors that are currently in the population. The selection process of DE-MC works via the usual Metropolis ratio which defines the probability with which a proposal is accepted. In tests with known uncertainty distributions, the efficiency of DE-MC with respect to random walk Metropolis with optimal multivariate Normal jumps ranged from 68% for small population sizes to 100% for large population sizes and even to 500% for the 97.5% point of a variable from a 50-dimensional Student distribution. Two Bayesian examples illustrate the potential of DE-MC in practice. DE-MC is shown to facilitate multidimensional updates in a multi-chain “Metropolis-within-Gibbs” sampling approach. The advantage of DE-MC over conventional MCMC are simplicity, speed of calculation and convergence, even for nearly collinear parameters and multimodal densities.


Block updating Evolutionary Monte Carlo Metropolis algorithm Population Markov Chain Monte Carlo Simulated Annealing Simulated Tempering Theophylline Kinetics 

Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  1. 1.BiometrisWageningen University and Research CentreWageningenThe Netherlands

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