Selection for the Predisposition to Catalepsy Enhances Depressive-like Traits in Mice
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- Bazovkina, D.V., Kulikov, A.V., Kondaurova, E.M. et al. Russ J Genet (2005) 41: 1002. doi:10.1007/s11177-005-0191-9
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Immobility reaction or catalepsy is a natural passive defensive (cryptic) behavioral response to the appearance of a predator. Selection for high predisposition to catalepsy has been performed in a population of (CBA × (CBA × AKR)) backcrosses of the crossing between mouse lines prone and resistant to catalepsy (CBA and AKR, respectively). A rapid increase in the number of animals with catalepsy has been observed: from 23% in backcrosses to 71% in the S3 generation. Selection for catalepsy does not affect mouse anxiety in the open field and plus-maze tests. However, S8 and S9 mice are characterized by a decreased motor activity in the open-field test and an increased immobility in the forced swim and tail suspension tests, which is interpreted as an increase in “ depressiveness.” The results indicate that genetically determined catalepsy is related to depressive-like characteristics of defensive behavior.