Russian Journal of Genetics

, Volume 41, Issue 9, pp 1002–1007

Selection for the Predisposition to Catalepsy Enhances Depressive-like Traits in Mice

  • D. V. Bazovkina
  • A. V. Kulikov
  • E. M. Kondaurova
  • N. K. Popova
General Genetics

DOI: 10.1007/s11177-005-0191-9

Cite this article as:
Bazovkina, D.V., Kulikov, A.V., Kondaurova, E.M. et al. Russ J Genet (2005) 41: 1002. doi:10.1007/s11177-005-0191-9

Abstract

Immobility reaction or catalepsy is a natural passive defensive (cryptic) behavioral response to the appearance of a predator. Selection for high predisposition to catalepsy has been performed in a population of (CBA × (CBA × AKR)) backcrosses of the crossing between mouse lines prone and resistant to catalepsy (CBA and AKR, respectively). A rapid increase in the number of animals with catalepsy has been observed: from 23% in backcrosses to 71% in the S3 generation. Selection for catalepsy does not affect mouse anxiety in the open field and plus-maze tests. However, S8 and S9 mice are characterized by a decreased motor activity in the open-field test and an increased immobility in the forced swim and tail suspension tests, which is interpreted as an increase in “ depressiveness.” The results indicate that genetically determined catalepsy is related to depressive-like characteristics of defensive behavior.

Copyright information

© MAIK "Nauka/Interperiodica" 2005

Authors and Affiliations

  • D. V. Bazovkina
    • 1
  • A. V. Kulikov
    • 1
  • E. M. Kondaurova
    • 1
  • N. K. Popova
    • 1
  1. 1.Institute of Cytology and Genetics, Siberian DivisionRussian Academy of SciencesNovosibirskRussia