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Fat sensing and metabolic syndrome

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Abstract

Overconsumption of dietary fat contributes to the development of obesity and metabolic syndrome. Recent evidence suggests that high dietary fat may promote these metabolic states not only by providing calories but also by inducing impaired control of energy balance. In normal metabolic states, fat interacts with various organs or receptors to generate signals for the regulation of energy balance. Many of these interactions are impaired by high-fat diets or in obesity, contributing to the development or maintenance of obesity. These impairments may arise largely from fundamental alterations in the hypothalamus where all peripheral signals are integrated to regulate energy balance. This review focuses on various mechanisms by which fat is sensed at different stages of ingestion, circulation, storage, and utilization to regulate food intake, and how these individual mechanisms are altered by high-fat diets or in obesity.

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Acknowledgments

I thank Dr. Joyce Richey at USC Keck School of Medicine for her critical reading of the manuscript. This work was supported by Basic Science Award #7-12-BS-214 from the American Diabetes Association.

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I have no conflicts of interest to disclose in connection with the manuscript.

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    Jang H. Youn

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Youn, J.H. Fat sensing and metabolic syndrome. Rev Endocr Metab Disord 15, 263–275 (2014). https://doi.org/10.1007/s11154-014-9300-1

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