, Volume 12, Issue 4, pp 289-302,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 08 Jul 2011

Synthesis and secretion of gonadotropins including structure-function correlates

Abstract

The synthesis and secretion of the gonadotropic hormones involves coordination of signal transduction, gene expression, protein translation, post-translational folding and modification and finally secretion. The production of biologically active gonadotropin thus requires appropriately folded and glycosylated subunits that assemble to form the heterodimeric hormone. Here we overview recent literature on regulation of gonadotropin subunit gene expression and current understanding of the assembly and secretion of biologically active gonadotropic hormones. Finally, we discuss the therapeutic potential of understanding glycosylation function towards designing new forms of gonadotropins based on observations of physiologically relevant parameters such as age related glycosylation changes.

Supported by NIH grant R01HD18407 (JAD) and P01AG029531 (GRB).