Reviews in Endocrine and Metabolic Disorders

, Volume 11, Issue 3, pp 199–204

6q24 transient neonatal diabetes

Article

DOI: 10.1007/s11154-010-9150-4

Cite this article as:
Temple, I.K. & Shield, J.P.H. Rev Endocr Metab Disord (2010) 11: 199. doi:10.1007/s11154-010-9150-4

Abstract

Transient Neonatal Diabetes (type 1) is the commonest cause of diabetes presenting in the first week of life. The majority of infants recover by 3 months of age but are predisposed to developing type 2 diabetes in later life. It is associated with low birth weight but rapid catch up by 1 year of life. The condition is usually due to genetic or epigenetic aberrations at an imprinted locus on chromosome 6q24 and can be sporadic or inherited. Early diagnosis alters medical treatment strategies and differentiates it from other types of early onset diabetes. In some individuals, diabetes may be the initial presentation of a more complex imprinting disorder due to recessive mutations in the gene ZFP57 and may be associated with other developmental problems.

Keywords

Transient neonatal diabetesPLAGL1ZFP57

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Academic Unit of Genetic MedicinePrincess Anne HospitalSouthamptonUK
  2. 2.Division of Human Genetics, School of MedicineUniversity of SouthamptonSouthamptonUK
  3. 3.Institute of Child Life & Health, School of MedicineUniversity of BristolBristolUK
  4. 4.Department of Child HealthBristol Royal Hospital for ChildrenBristolUK