Reading and Writing

, Volume 20, Issue 1, pp 27–49

Back to Africa: Tracing Dyslexia Genes in East Africa

  • Elena L. Grigorenko
  • Adam Naples
  • Joseph Chang
  • Christina Romano
  • Damaris Ngorosho
  • Selemani Kungulilo
  • Matthew Jukes
  • Donald Bundy
Article

DOI: 10.1007/s11145-006-9017-y

Cite this article as:
Grigorenko, E.L., Naples, A., Chang, J. et al. Read Writ (2007) 20: 27. doi:10.1007/s11145-006-9017-y

Abstract

A sample of Swahili-speaking probands with reading difficulties was identified from a large representative sample of 1,500 school children in the rural areas of Tanzania. Families of these probands (n = 88) were invited to participate in the study. The proband and his/her siblings received a battery of reading-related tasks and performance on these tasks was recorded and treated as phenotypic data. Molecular-genetic analyses were carried out with 47 highly polymorphic markers spanning three previously identified regions of interest harboring susceptibility loci for reading difficulties: 2p, 6p, and 15q (DYX1–DYX3). The analyses revealed the involvement of these regions in the development of reading difficulties in Swahili. The linkage signals are especially pronounced for time (compared with error) indicators of reading difficulties. These findings are easily interpretable because in transparent languages such as Swahili deficits in reading are more related to the rate/speed of reading and reading-related processes than to the number of errors made. In short, the study incrementally advances the field by adding an understudied language and an understudied population to the variety of languages and populations in the field of molecular-genetic studies of reading difficulties.

Keywords

Candidate genes Dyslexia Linkage analyses Regional mapping Swahili 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Elena L. Grigorenko
    • 1
    • 2
    • 3
    • 10
  • Adam Naples
    • 2
  • Joseph Chang
    • 4
  • Christina Romano
    • 1
  • Damaris Ngorosho
    • 5
  • Selemani Kungulilo
    • 6
  • Matthew Jukes
    • 7
    • 8
  • Donald Bundy
    • 8
  1. 1.Child Study CenterYale University Medical SchoolNew HavenUSA
  2. 2.Yale University PACE CenterNew HavenUSA
  3. 3.Department of PsychologyMoscow State UniversityMoscowRussia
  4. 4.Department of StatisticsYale UniversityNew HavenUSA
  5. 5.The Agency for the Development of Educational ManagementBagamoyoTanzania
  6. 6.Muhimbili University College of Health SciencesDar-es-SalaamTanzania
  7. 7.Department of Infectious Disease EpidemiologyImperial College, Partnership for Child DevelopmentLondonUK
  8. 8.Institute of Education, School of Lifelong Education and International DevelopmentUniversity of LondonLondonUK
  9. 9.School Health and NutritionWorld BankWashingtonUSA
  10. 10.Child Study CenterYale University Medical SchoolNew HavenUSA
  11. 11.Child Study CenterYale University Medical SchoolNew HavenUSA