Reaction Kinetics, Mechanisms and Catalysis

, Volume 103, Issue 2, pp 443–449

Enantio-differentiating hydrogenation of methyl acetoacetate over tartaric acid-NaBr-modified Raney nickel catalyst under a low hydrogen pressure

  • Tsutomu Osawa
  • Mari Onogi
  • I-Yin Sandy Lee
  • Tadao Harada
Article

DOI: 10.1007/s11144-011-0322-3

Cite this article as:
Osawa, T., Onogi, M., Lee, IY.S. et al. Reac Kinet Mech Cat (2011) 103: 443. doi:10.1007/s11144-011-0322-3

Abstract

The enantio-differentiating hydrogenation of methyl acetoacetate was carried out over a (R,R)-tartaric acid-NaBr-modified Raney nickel catalyst under low hydrogen pressure. The rate of the supply of hydrogen on the catalyst surface would be an important factor for attaining high enantioselectivity, especially under low hydrogen pressure. A maximum enantioselectivity of 82% was attained under an initial hydrogen pressure of 0.2 MPa at 333 K with a high stirring rate.

Keywords

Tartaric acid-modified nickelLow hydrogen pressureMethyl acetoacetateStirring rateEnantio-differentiating hydrogenation

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2011

Authors and Affiliations

  • Tsutomu Osawa
    • 1
  • Mari Onogi
    • 1
  • I-Yin Sandy Lee
    • 1
  • Tadao Harada
    • 2
  1. 1.Graduate School of Science and Engineering for ResearchUniversity of ToyamaToyamaJapan
  2. 2.Faculty of Science and TechnologyRyukoku UniversityOtsuJapan