Reaction Kinetics and Catalysis Letters

, Volume 95, Issue 2, pp 385–390

Copper(II) trifluoroacetate catalyzed synthesis of 3,4- dihydropyrimidin-2(1H)-ones under solvent-free conditions

Authors

  • Dailei Song
    • Department of Chemistry, School of Chemistry and Materials ScienceLiaoning Shihua University
  • Runxia Wang
    • Department of Chemistry, School of Chemistry and Materials ScienceLiaoning Shihua University
  • Yongli Chen
    • Department of Chemistry, School of Chemistry and Materials ScienceLiaoning Shihua University
  • Shaohua Zhang
    • Department of Chemistry, School of Chemistry and Materials ScienceLiaoning Shihua University
  • Chunsheng Liu
    • Department of Chemistry, School of Chemistry and Materials ScienceLiaoning Shihua University
    • Department of Chemistry, School of Chemistry and Materials ScienceLiaoning Shihua University
Article

DOI: 10.1007/s11144-008-5379-2

Cite this article as:
Song, D., Wang, R., Chen, Y. et al. React Kinet Catal Lett (2008) 95: 385. doi:10.1007/s11144-008-5379-2

Abstract

A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea using copper(II) trifluoroacetate as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction condition, this new method has the advantage of good to excellent yields and short reaction time.

Keywords

3,4-dihydropyrimidin-2(1H)-onescopper(II) trifluoroacetateBiginelli reactionsolvent-free

Copyright information

© Springer Science+Business Media, LLC. 2008