Article

Reaction Kinetics and Catalysis Letters

, Volume 95, Issue 2, pp 385-390

First online:

Copper(II) trifluoroacetate catalyzed synthesis of 3,4- dihydropyrimidin-2(1H)-ones under solvent-free conditions

  • Dailei SongAffiliated withDepartment of Chemistry, School of Chemistry and Materials Science, Liaoning Shihua University
  • , Runxia WangAffiliated withDepartment of Chemistry, School of Chemistry and Materials Science, Liaoning Shihua University
  • , Yongli ChenAffiliated withDepartment of Chemistry, School of Chemistry and Materials Science, Liaoning Shihua University
  • , Shaohua ZhangAffiliated withDepartment of Chemistry, School of Chemistry and Materials Science, Liaoning Shihua University
  • , Chunsheng LiuAffiliated withDepartment of Chemistry, School of Chemistry and Materials Science, Liaoning Shihua University
  • , Genxiang LuoAffiliated withDepartment of Chemistry, School of Chemistry and Materials Science, Liaoning Shihua University Email author 

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Abstract

A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea using copper(II) trifluoroacetate as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction condition, this new method has the advantage of good to excellent yields and short reaction time.

Keywords

3,4-dihydropyrimidin-2(1H)-ones copper(II) trifluoroacetate Biginelli reaction solvent-free