, Volume 95, Issue 2, pp 385-390
Date: 23 Dec 2008

Copper(II) trifluoroacetate catalyzed synthesis of 3,4- dihydropyrimidin-2(1H)-ones under solvent-free conditions

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A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea using copper(II) trifluoroacetate as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction condition, this new method has the advantage of good to excellent yields and short reaction time.