Skip to main content
SpringerLink
Log in

Factors associated with the quality of life of Korean COPD patients as measured by the EQ-5D

  • Published:
Quality of Life Research Aims and scope Submit manuscript

Abstract

Purpose

This study evaluated the health-related quality of life measured using the EuroQol five-dimension questionnaire (EQ-5D) and the degree of airway obstruction in a Korean population using Korea National Health and Nutritional Examination Survey (KNHANES IV–V, 2007–2010) data.

Methods

A cross-sectional analysis examined 2356 subjects (1178 COPD patients, 1178 control subjects) aged ≥40 years and performed reliable spirometry as part of KNHANES IV–V. Baseline EQ-5D visual analog scale (VAS) and EQ-5D utility scores were obtained. A Tobit censored regression model was used to evaluate factors affecting EQ-5D in COPD patients.

Results

The EQ-5D VAS and EQ-5D utility scores were significantly different among the COPD severity groups (P < 0.05). The mean EQ-5D VAS scores for patients with mild, moderate, and severe COPD were 73.0 (SD 18.6), 70.8 (19.1), and 60.9 (23.4), respectively. The mean utility scores were 0.90 (0.14) for patients with mild COPD, 0.89 (0.14) for patients with moderate COPD, and 0.84 (0.15) for patients with severe COPD. Factors influencing the EQ-5D utility score in patients with COPD were age, gender, household income, education level, severe airflow obstruction, and comorbidities.

Conclusions

The EQ-5D score could be a useful instrument for evaluating the quality of life of COPD patients in Korea. In Korean COPD patients, the main determinants of EQ-5D scores include older age, female gender, lower household income, lower education level, severe airflow obstruction, and many comorbid diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Rabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., et al. (2007). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease—GOLD executive summary. American Journal of Respiratory and Critical Care Medicine, 176(6), 532–555.

    Article  PubMed  Google Scholar 

  2. Decramer, M., Sibille, Y., Bush, A., Carlsen, K. H., Rabe, K. F., Clancy, L., et al. (2011). The European Union conference on chronic respiratory disease: Purpose and conclusions. European Respiratory Journal, 37(4), 738–742.

    Article  CAS  PubMed  Google Scholar 

  3. Vestbo, J., Hurd, S. S., Agusti, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., et al. (2013). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. American Journal of Respiratory and Critical Care Medicine, 187(4), 347–365.

    Article  CAS  PubMed  Google Scholar 

  4. Decramer, M., Celli, B., Kesten, S., Lystig, T., Mehra, S., & Tashkin, D. P. (2009). Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): A prespecified subgroup analysis of a randomised controlled trial. Lancet, 374(9696), 1171–1178.

    Article  CAS  PubMed  Google Scholar 

  5. Jenkins, C. R., Jones, P. W., Calverley, P. M., Celli, B., Anderson, J. A., Ferguson, G. T., et al. (2009). Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: Analysis from the randomised, placebo-controlled TORCH study. Respiratory Research, 10, 59.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Jones, P. W. (2009). Health status and the spiral of decline. COPD, 6(1), 59–63.

    Article  PubMed  Google Scholar 

  7. Guyatt, G. H., Feeny, D. H., & Patrick, D. L. (1993). Measuring health-related quality of life. Annals of Internal Medicine, 118(8), 622–629.

    Article  CAS  PubMed  Google Scholar 

  8. Carrasco Garrido, P., de Miguel Diez, J., Rejas Gutierrez, J., Centeno, A. M., Gobartt Vazquez, E., Gil de Miguel, A., et al. (2006). Negative impact of chronic obstructive pulmonary disease on the health-related quality of life of patients. Results of the EPIDEPOC study. Health and Quality of Life Outcomes, 4, 31.

    Article  PubMed  Google Scholar 

  9. Rutten-van, M. P. M., Oostenbrink, J. B., Tashkin, D. P., Burkhart, D., & Monz, B. U. (2006). Does quality of life of COPD patients as measured by the generic EuroQol five-dimension questionnaire differentiate between COPD severity stages? Chest, 130(4), 1117–1128.

    Article  Google Scholar 

  10. Ferrer, M., Alonso, J., Morera, J., Marrades, R. M., Khalaf, A., Aguar, M. C., et al. (1997). Chronic obstructive pulmonary disease stage and health-related quality of life. The quality of life of chronic obstructive pulmonary disease study group. Annals of Internal Medicine, 127(12), 1072–1079.

    Article  CAS  PubMed  Google Scholar 

  11. DiBonaventura, M., Paulose-Ram, R., Su, J., McDonald, M., Zou, K. H., Wagner, J. S., et al. (2012). The impact of COPD on quality of life, productivity loss, and resource use among the elderly United States workforce. COPD, 9(1), 46–57.

    Article  PubMed  Google Scholar 

  12. Burgel, P. R., Escamilla, R., Perez, T., Carre, P., Caillaud, D., Chanez, P., et al. (2013). Impact of comorbidities on COPD-specific health-related quality of life. Respiratory Medicine, 107(2), 233–241.

    Article  PubMed  Google Scholar 

  13. Weldam, S. W., Lammers, J. W., Decates, R. L., & Schuurmans, M. J. (2013). Daily activities and health-related quality of life in patients with chronic obstructive pulmonary disease: Psychological determinants: A cross-sectional study. Health and Quality of Life Outcomes, 11, 190.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Popa-Velea, O., & Purcarea, V. (2014). Psychological factors mediating health-related quality of life in COPD. Journal of Medicine and Life, 7(1), 100–103.

    PubMed Central  CAS  PubMed  Google Scholar 

  15. Yoo, K. H., Kim, Y. S., Sheen, S. S., Park, J. H., Hwang, Y. I., Kim, S. H., et al. (2011). Prevalence of chronic obstructive pulmonary disease in Korea: The fourth Korean National Health and Nutrition Examination Survey, 2008. Respirology, 16(4), 659–665.

    Article  PubMed  Google Scholar 

  16. Kim, S. H., Oh, Y. M., & Jo, M. W. (2014). Health-related quality of life in chronic obstructive pulmonary disease patients in Korea. Health and Quality of Life Outcomes, 12, 57.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Miller, M. R., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R., Coates, A., et al. (2007). Standardisation of spirometry. Revue des Maladies Respiratoires, 24(3), S27–S49.

    Article  Google Scholar 

  18. Rabin, R., & de Charro, F. (2001). EQ-5D: A measure of health status from the EuroQol Group. Annals of Medicine, 33(5), 337–343.

    Article  CAS  PubMed  Google Scholar 

  19. Brooks, R. (1996). EuroQol: The current state of play. Health Policy, 37(1), 53–72.

    Article  CAS  PubMed  Google Scholar 

  20. group E. (1990). EuroQol–a new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199–208.

    Article  Google Scholar 

  21. Lee, Y. K., Nam, H. S., Chuang, L. H., Kim, K. Y., Yang, H. K., Kwon, I. S., et al. (2009). South Korean time trade-off values for EQ-5D health states: Modeling with observed values for 101 health states. Value in Health, 12(8), 1187–1193.

    Article  PubMed  Google Scholar 

  22. Pickard, A. S., Yang, Y., & Lee, T. A. (2011). Comparison of health-related quality of life measures in chronic obstructive pulmonary disease. Health and Quality of Life Outcomes, 9, 26.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Jones, P. W., Quirk, F. H., Baveystock, C. M. (1991). The St George’s Respiratory Questionnaire. Respir Med, 85 Suppl B, 25–31; discussion 33–27.

  24. Glasziou, P., Alexander, J., Beller, E., & Clarke, P. (2007). Which health-related quality of life score? A comparison of alternative utility measures in patients with Type 2 diabetes in the ADVANCE trial. Health and Quality of Life Outcomes, 5, 21.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Punekar, Y. S., Rodriguez-Roisin, R., Sculpher, M., Jones, P., & Spencer, M. (2007). Implications of chronic obstructive pulmonary disease (COPD) on patients’ health status: A western view. Respiratory Medicine, 101(3), 661–669.

    Article  PubMed  Google Scholar 

  26. Antonelli-Incalzi, R., Imperiale, C., Bellia, V., Catalano, F., Scichilone, N., Pistelli, R., et al. (2003). Do GOLD stages of COPD severity really correspond to differences in health status? European Respiratory Journal, 22(3), 444–449.

    Article  CAS  PubMed  Google Scholar 

  27. Yeo, J., Karimova, G., & Bansal, S. (2006). Co-morbidity in older patients with COPD—its impact on health service utilisation and quality of life, a community study. Age and Ageing, 35(1), 33–37.

    Article  CAS  PubMed  Google Scholar 

  28. Ketelaars, C. A., Schlosser, M. A., Mostert, R., Huyer Abu-Saad, H., Halfens, R. J., & Wouters, E. F. (1996). Determinants of health-related quality of life in patients with chronic obstructive pulmonary disease. Thorax, 51(1), 39–43.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. Carrasco-Garrido, P., de Miguel-Diez, J., Rejas-Gutierrez, J., Martin-Centeno, A., Gobartt-Vazquez, E., Hernandez-Barrera, V., et al. (2009). Characteristics of chronic obstructive pulmonary disease in Spain from a gender perspective. BMC Pulmonary Medicine, 9, 2.

    Article  PubMed Central  PubMed  Google Scholar 

  30. Naberan, K., Azpeitia, A., Cantoni, J., & Miravitlles, M. (2012). Impairment of quality of life in women with chronic obstructive pulmonary disease. Respiratory Medicine, 106(3), 367–373.

    Article  PubMed  Google Scholar 

  31. Miravitlles, M., Naberan, K., Cantoni, J., & Azpeitia, A. (2011). Socioeconomic status and health-related quality of life of patients with chronic obstructive pulmonary disease. Respiration, 82(5), 402–408.

    Article  PubMed  Google Scholar 

  32. Johannessen, A., Eagan, T. M., Omenaas, E. R., Bakke, P. S., & Gulsvik, A. (2010). Socioeconomic risk factors for lung function decline in a general population. European Respiratory Journal, 36(3), 480–487.

    Article  CAS  PubMed  Google Scholar 

  33. Tsukino, M., Nishimura, K., Ikeda, A., Koyama, H., Mishima, M., & Izumi, T. (1996). Physiologic factors that determine the health-related quality of life in patients with COPD. Chest, 110(4), 896–903.

    Article  CAS  PubMed  Google Scholar 

  34. Stahl, E., Lindberg, A., Jansson, S. A., Ronmark, E., Svensson, K., Andersson, F., et al. (2005). Health-related quality of life is related to COPD disease severity. Health and Quality of Life Outcomes, 3, 56.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Jackson, B. E., Coultas, D. B., Suzuki, S., Singh, K. P., & Bae, S. (2013). Rural-urban disparities in quality of life among patients with COPD. The Journal of Rural Health, 29(Suppl 1), s62–s69.

    Article  PubMed Central  PubMed  Google Scholar 

  36. Wilke, S., Janssen, D. J., Wouters, E. F., Schols, J. M., Franssen, F. M., & Spruit, M. A. (2012). Correlations between disease-specific and generic health status questionnaires in patients with advanced COPD: A one-year observational study. Health and Quality of Life Outcomes, 10, 98.

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

The authors are grateful to Mi Kyung Song and Bo Kyung Ma, Biostatistics Collaboration Unit, Yonsei University College of Medicine, for assistance with the statistical analyses. We sincerely acknowledge the efforts of the KNHANES investigators of the Korean Centers for Disease Control.

Conflict of interest

No potential financial or personal relationship relevant to this article is reported.

Author information

Authors and Affiliations

  1. Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonseiro, Seodaemun-gu, Seoul, 120-752, Republic of Korea

    Ji Young Hong, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Ae Kang, Se Kyu Kim, Joon Chang & Young Sam Kim

Authors
  1. Ji Young Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Song Yee Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kyung Soo Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Eun Young Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ji Ye Jung
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Moo Suk Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Young Ae Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Se Kyu Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Joon Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Young Sam Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Young Sam Kim.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hong, J.Y., Kim, S.Y., Chung, K.S. et al. Factors associated with the quality of life of Korean COPD patients as measured by the EQ-5D. Qual Life Res 24, 2549–2558 (2015). https://doi.org/10.1007/s11136-015-0979-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11136-015-0979-6

Keywords

Search

Navigation