Quality of Life Research

, Volume 22, Issue 10, pp 2801–2808

Psychometric evaluation of the National Eye Institute Visual Function Questionnaire and Visual Function Questionnaire Utility Index in patients with non-infectious intermediate and posterior uveitis

  • Rupali K. Naik
  • Katharine S. Gries
  • Anne M. Rentz
  • Jonathan W. Kowalski
  • Dennis A. Revicki
Article

DOI: 10.1007/s11136-013-0412-y

Cite this article as:
Naik, R.K., Gries, K.S., Rentz, A.M. et al. Qual Life Res (2013) 22: 2801. doi:10.1007/s11136-013-0412-y

Abstract

Objective

To evaluate the psychometric properties of the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) and Visual Function Questionnaire Utility Index (VFQ-UI) in patients with non-infectious intermediate and posterior uveitis.

Methods

Secondary analysis of pooled data from a 26-week, multicenter, masked, randomized, sham-controlled Phase 3 clinical trial. Health-related quality of life was assessed using the NEI VFQ-25, the EQ-5D, and SF-36. Internal consistency reliability, reproducibility, convergent validity, and known groups of BCVA and vitreous haze severity were assessed. Clinically significant difference was assessed using anchor-based and distribution-based methods.

Results

The study included 224 subjects with non-infectious intermediate (80.4 %) or posterior uveitis (19.6 %). The NEI VFQ-25 and the VFQ-UI demonstrated good internal consistency (Cronbach’s alpha 0.87–0.94) and test–retest reliability (ICCs 0.58–0.88). Spearman’s product–moment rank correlations between the NEI VFQ-25 and VFQ-UI scores and the SF-6D, EQ-5D, and BCVA ranged from small to moderate. There was a significant association between visual functioning and known groups of visual acuity (p < 0.05). Clinical significance, using the anchor-based method (difference between visual acuity groups ≥10–<15 letter better and no change), was 10.2 for change from baseline to week 26 for the NEI VFQ-25 composite score and 0.05 for the VFQ-UI. Using the distribution-based method, the clinical significance was 3.86 for the composite score and 0.04 for the VFQ-UI.

Conclusion

The NEI VFQ-25 and the VFQ-UI are reliable and valid measures of vision-related functioning and preference-based status in patients with non-infectious intermediate and posterior uveitis.

Keywords

Ocular diseaseVision-related functioningNEI VFQ-25VFQ-UIUveitisPsychometric evaluation

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Rupali K. Naik
    • 1
  • Katharine S. Gries
    • 2
  • Anne M. Rentz
    • 2
  • Jonathan W. Kowalski
    • 1
  • Dennis A. Revicki
    • 2
  1. 1.Global Health Outcomes Strategy and Research, Allergan Inc.IrvineUSA
  2. 2.Outcomes Research, United BioSource CorporationBethesdaUSA