Quality of Life Research

, Volume 20, Issue 2, pp 205–214

External validity of the pediatric cardiac quality of life inventory

  • Bradley S. Marino
  • Dennis Drotar
  • Amy Cassedy
  • Richard Davis
  • Ryan S. Tomlinson
  • Katelyn Mellion
  • Kathleen Mussatto
  • Lynn Mahony
  • Jane W. Newburger
  • Elizabeth Tong
  • Mitchell I. Cohen
  • Mark A. Helfaer
  • Anne E. Kazak
  • Jo Wray
  • Gil Wernovsky
  • Judy A. Shea
  • Richard Ittenbach
Article

DOI: 10.1007/s11136-010-9731-4

Cite this article as:
Marino, B.S., Drotar, D., Cassedy, A. et al. Qual Life Res (2011) 20: 205. doi:10.1007/s11136-010-9731-4

Abstract

Purpose

The Pediatric Cardiac Quality of Life Inventory (PCQLI) is a disease-specific, health-related quality of life (HRQOL) measure for pediatric heart disease (HD). The purpose of this study was to demonstrate the external validity of PCQLI scores.

Methods

The PCQLI development site (Development sample) and six geographically diverse centers in the United States (Composite sample) recruited pediatric patients with acquired or congenital HD. Item response option variability, scores [Total (TS); Disease Impact (DI) and Psychosocial Impact (PI) subscales], patterns of correlation, and internal consistency were compared between samples.

Results

A total of 3,128 patients and parent participants (1,113 Development; 2,015 Composite) were analyzed. Response option variability patterns of all items in both samples were acceptable. Inter-sample score comparisons revealed no differences. Median item–total (Development, 0.57; Composite, 0.59) and item–subscale (Development, DI 0.58, PI 0.59; Composite, DI 0.58, PI 0.56) correlations were moderate. Subscale–subscale (0.79 for both samples) and subscale—total (Development, DI 0.95, PI 0.95; Composite, DI 0.95, PI 0.94) correlations and internal consistency (Development, TS 0.93, DI 0.90, PI 0.84; Composite, TS 0.93, DI 0.89, PI 0.85) were high in both samples.

Conclusion

PCQLI scores are externally valid across the US pediatric HD population and may be used for multi-center HRQOL studies.

Keywords

Health-related quality of lifePediatricsCongenital heart diseaseAcquired heart diseaseExternal validity

Abbreviations

HD

Heart disease

HRQOL

Health-related quality of life

PCQLI

Pediatric cardiac quality of life inventory

DI

Disease impact

PI

Psychosocial impact

TS

Total score

S/P

Status post

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Bradley S. Marino
    • 1
    • 2
  • Dennis Drotar
    • 3
  • Amy Cassedy
    • 4
  • Richard Davis
    • 1
  • Ryan S. Tomlinson
    • 1
  • Katelyn Mellion
    • 1
  • Kathleen Mussatto
    • 5
  • Lynn Mahony
    • 6
  • Jane W. Newburger
    • 7
  • Elizabeth Tong
    • 8
  • Mitchell I. Cohen
    • 9
  • Mark A. Helfaer
    • 10
  • Anne E. Kazak
    • 11
  • Jo Wray
    • 12
  • Gil Wernovsky
    • 13
  • Judy A. Shea
    • 14
  • Richard Ittenbach
    • 4
  1. 1.Department of Pediatrics, Division of Cardiology, Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiUSA
  2. 2.Department of Pediatrics, Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiUSA
  3. 3.Department of Pediatrics, Division of Behavioral and Clinical Psychology, Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiUSA
  4. 4.Department of Pediatrics, Division of Biostatistics, Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiUSA
  5. 5.Department of Pediatrics, Division of CardiologyThe Children’s Hospital of WisconsinMilwaukeeUSA
  6. 6.Department of Pediatrics, Division of CardiologyThe University of Texas Southwestern Medical Center DallasDallasUSA
  7. 7.Department of Cardiology, Children’s Hospital Boston, and Department of PediatricsHarvard Medical SchoolBostonUSA
  8. 8.Department of Pediatrics, Division of Cardiology, The University of California San Francisco Children’s HospitalUniversity of San Francisco School of MedicineSan FranciscoUSA
  9. 9.Department of Pediatrics, Division of CardiologyPhoenix Children’s HospitalPhoenixUSA
  10. 10.Department of Anesthesiology and Critical Care, Division of Critical Care MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  11. 11.Department of Pediatrics, Division of PsychologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  12. 12.Department of Paediatric CardiologyThe Royal Brompton and Harefield NHS TrustLondonUK
  13. 13.Department of Pediatrics, Division of CardiologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  14. 14.Department of Medicine, Division of General Internal MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA