Quality of Life Research

, Volume 20, Issue 1, pp 119–131

Impact and characteristics of quality of life in Japanese patients with multiple sclerosis

  • Hiromi Kikuchi
  • Nobuhiro Mifune
  • Masaaki Niino
  • Sadayoshi Ohbu
  • Jun-ichi Kira
  • Tatsuo Kohriyama
  • Kohei Ota
  • Masami Tanaka
  • Hirofumi Ochi
  • Shunya Nakane
  • Masaji Maezawa
  • Seiji Kikuchi
Article

DOI: 10.1007/s11136-010-9725-2

Cite this article as:
Kikuchi, H., Mifune, N., Niino, M. et al. Qual Life Res (2011) 20: 119. doi:10.1007/s11136-010-9725-2

Abstract

Purpose

To evaluate health-related quality of life (HRQOL) in Japanese patients with multiple sclerosis (MS) and investigate associations between the results of these QOL assessments and disease severity.

Methods

One-hundred sixty-three Japanese MS patients completed a questionnaire battery comprising the Functional Assessment of MS (FAMS), the Nottingham Adjustment Scale-Japanese version (NAS-J), and the European QOL scale (EQ-5D). Additional five factors affecting QOL as identified by MS patients in a focus group interview were also investigated: employment status, change of income, availability of disease information, communication with medical staff, and care received. Disease severity was determined using the Expanded Disability Status Scale (EDSS).

Results

There was a strong negative correlation of the subscale scores for mobility, symptoms, emotional well-being, thinking and fatigue, and additional concerns on the FAMS with EDSS score. For the NAS-J, only acceptance of the condition was correlated with disease severity. Among the five additional aspects of the condition identified by patients, employment status, income, and disease information were shown to be important for maintaining QOL in patients with MS.

Conclusions

Support for finding employment and having increased or maintained household income and readily available information about the disease contribute to improving QOL in Japanese MS patients.

Keywords

Multiple sclerosis Quality of life Employment Income 

Abbreviations

MS

Multiple sclerosis

CNS

Central nervous system

QOL

Quality of life

HRQOL

Health-related quality of life

MSQLI

Multiple Sclerosis Quality of Life Inventory

HAQUAMS

Hamburg Quality of Life Questionnaire in Multiple Sclerosis

MSIS-29

Multiple Sclerosis Impact Scale-29

FAMS

Functional Assessment of Multiple Sclerosis

NAS-J

Nottingham Adjustment Scale-Japanese version

EQ-5D

EuroQol-5D

FGI

Focus group interview

EDSS

Expanded Disability Status Scale

ACTH

Adrenocorticotropic hormone

CBT

Cognitive behavioral therapy

RT

Relaxation training

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Hiromi Kikuchi
    • 1
    • 2
  • Nobuhiro Mifune
    • 3
  • Masaaki Niino
    • 4
  • Sadayoshi Ohbu
    • 5
  • Jun-ichi Kira
    • 6
  • Tatsuo Kohriyama
    • 7
  • Kohei Ota
    • 8
  • Masami Tanaka
    • 9
  • Hirofumi Ochi
    • 6
  • Shunya Nakane
    • 10
  • Masaji Maezawa
    • 2
  • Seiji Kikuchi
    • 11
  1. 1.College of NursingSapporo City UniversitySapporoJapan
  2. 2.Department of Healthcare Systems ResearchHokkaido University Graduate School of MedicineSapporoJapan
  3. 3.Department of Behavioral ScienceHokkaido University Graduate School of LettersSapporoJapan
  4. 4.Department of NeurologyHokkaido University Graduate School of MedicineKita-ku, SapporoJapan
  5. 5.Department of SociologyRikkyo UniversityTokyoJapan
  6. 6.Department of Neurology, Neurological Institute, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  7. 7.Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan
  8. 8.Faculty of ScienceTokyo University of ScienceTokyoJapan
  9. 9.MS Center, Utano National HospitalKyotoJapan
  10. 10.Department of NeurologyNagasaki Kawatana Medical CenterKawatanaJapan
  11. 11.Department of NeurologySapporo-Minami National HospitalSapporoJapan